Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin

Abstract Background Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous matrix scaffold which regulates inflammation by stimulating cytokines and growth factors that are involved in the immune response. L-PRF is suggested as a viable adjunctive method to surgical interventions due to its ad...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Öznur Özalp, Nelli Yıldırımyan, Canan Öztürk, Burak Kocabalkan, Göksel Şimşek Kaya, Alper Sindel, Mehmet Ali Altay
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Medication-related osteonecrosis of the jaw Osteonecrosis Surgical treatment Adjunctive therapy Leukocyte and platelet rich fibrin Platelet concentrates Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/d62f1d65ff764804a90a4070f6ef2f42
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d62f1d65ff764804a90a4070f6ef2f42
record_format	dspace
spelling	oai:doaj.org-article:d62f1d65ff764804a90a4070f6ef2f422021-12-05T12:20:30ZPromising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin10.1186/s12903-021-01965-71472-6831https://doaj.org/article/d62f1d65ff764804a90a4070f6ef2f422021-12-01T00:00:00Zhttps://doi.org/10.1186/s12903-021-01965-7https://doaj.org/toc/1472-6831Abstract Background Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous matrix scaffold which regulates inflammation by stimulating cytokines and growth factors that are involved in the immune response. L-PRF is suggested as a viable adjunctive method to surgical interventions due to its advantages on tissue healing. This study aims to retrospectively evaluate the adjunctive role of L-PRF in surgically treated medication-related osteonecrosis of the jaws (MRONJ) patients. Methods Between January 2012 and December 2020, patients with AAOMS stage II and III MRONJ lesions, who were treated surgically with adjunctive use of L-PRF in the authors’ institution were enrolled. Surgical interventions consisted of either marginal resection or sequestrectomy with peripheral ostectomy (SPO) or curettage and L-PRF application. Medical records of these patients were retrospectively reviewed and healing was assessed according to certain parameters including mucosal closure and presence of infection, exposed bone, fistula or radiologic markers of disease progression for a minimum of 12 months. Results Thirteen patients (7 women and 6 men) with an average age of 72.4 years (± 10.61, range 54–84) were included in the study, nine of whom had AAOMS stage III and four stage II MRONJ. Three patients had a marginal resection, nine patients had sequestrectomy with peripheral ostectomy (SPO) and one patient underwent a curettage procedure. All marginal resection and six SPO patients showed complete healing while four patients, who had SPO or curettage experienced incomplete healing. Mean follow up was 20.1 ± 18.29 months. Conclusion The use of L-PRF may be a favorable adjunctive option in the treatment of MRONJ owing to its favorable effects on tissue repair, ease of application, minimally invasive and cost-effective character and autogenous nature. Trial registration Retrospectively registered.Öznur ÖzalpNelli YıldırımyanCanan ÖztürkBurak KocabalkanGöksel Şimşek KayaAlper SindelMehmet Ali AltayBMCarticleMedication-related osteonecrosis of the jawOsteonecrosisSurgical treatmentAdjunctive therapyLeukocyte and platelet rich fibrinPlatelet concentratesDentistryRK1-715ENBMC Oral Health, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medication-related osteonecrosis of the jaw Osteonecrosis Surgical treatment Adjunctive therapy Leukocyte and platelet rich fibrin Platelet concentrates Dentistry RK1-715
spellingShingle	Medication-related osteonecrosis of the jaw Osteonecrosis Surgical treatment Adjunctive therapy Leukocyte and platelet rich fibrin Platelet concentrates Dentistry RK1-715 Öznur Özalp Nelli Yıldırımyan Canan Öztürk Burak Kocabalkan Göksel Şimşek Kaya Alper Sindel Mehmet Ali Altay Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin
description	Abstract Background Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous matrix scaffold which regulates inflammation by stimulating cytokines and growth factors that are involved in the immune response. L-PRF is suggested as a viable adjunctive method to surgical interventions due to its advantages on tissue healing. This study aims to retrospectively evaluate the adjunctive role of L-PRF in surgically treated medication-related osteonecrosis of the jaws (MRONJ) patients. Methods Between January 2012 and December 2020, patients with AAOMS stage II and III MRONJ lesions, who were treated surgically with adjunctive use of L-PRF in the authors’ institution were enrolled. Surgical interventions consisted of either marginal resection or sequestrectomy with peripheral ostectomy (SPO) or curettage and L-PRF application. Medical records of these patients were retrospectively reviewed and healing was assessed according to certain parameters including mucosal closure and presence of infection, exposed bone, fistula or radiologic markers of disease progression for a minimum of 12 months. Results Thirteen patients (7 women and 6 men) with an average age of 72.4 years (± 10.61, range 54–84) were included in the study, nine of whom had AAOMS stage III and four stage II MRONJ. Three patients had a marginal resection, nine patients had sequestrectomy with peripheral ostectomy (SPO) and one patient underwent a curettage procedure. All marginal resection and six SPO patients showed complete healing while four patients, who had SPO or curettage experienced incomplete healing. Mean follow up was 20.1 ± 18.29 months. Conclusion The use of L-PRF may be a favorable adjunctive option in the treatment of MRONJ owing to its favorable effects on tissue repair, ease of application, minimally invasive and cost-effective character and autogenous nature. Trial registration Retrospectively registered.
format	article
author	Öznur Özalp Nelli Yıldırımyan Canan Öztürk Burak Kocabalkan Göksel Şimşek Kaya Alper Sindel Mehmet Ali Altay
author_facet	Öznur Özalp Nelli Yıldırımyan Canan Öztürk Burak Kocabalkan Göksel Şimşek Kaya Alper Sindel Mehmet Ali Altay
author_sort	Öznur Özalp
title	Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin
title_short	Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin
title_full	Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin
title_fullStr	Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin
title_full_unstemmed	Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin
title_sort	promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d62f1d65ff764804a90a4070f6ef2f42
work_keys_str_mv	AT oznurozalp promisingresultsofsurgicalmanagementofadvancedmedicationrelatedosteonecrosisofthejawsusingadjunctiveleukocyteandplateletrichfibrin AT nelliyıldırımyan promisingresultsofsurgicalmanagementofadvancedmedicationrelatedosteonecrosisofthejawsusingadjunctiveleukocyteandplateletrichfibrin AT cananozturk promisingresultsofsurgicalmanagementofadvancedmedicationrelatedosteonecrosisofthejawsusingadjunctiveleukocyteandplateletrichfibrin AT burakkocabalkan promisingresultsofsurgicalmanagementofadvancedmedicationrelatedosteonecrosisofthejawsusingadjunctiveleukocyteandplateletrichfibrin AT gokselsimsekkaya promisingresultsofsurgicalmanagementofadvancedmedicationrelatedosteonecrosisofthejawsusingadjunctiveleukocyteandplateletrichfibrin AT alpersindel promisingresultsofsurgicalmanagementofadvancedmedicationrelatedosteonecrosisofthejawsusingadjunctiveleukocyteandplateletrichfibrin AT mehmetalialtay promisingresultsofsurgicalmanagementofadvancedmedicationrelatedosteonecrosisofthejawsusingadjunctiveleukocyteandplateletrichfibrin
_version_	1718372043900059648

Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin

Ejemplares similares