Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species

The dysregulation of glucose metabolism that includes the modification of biomolecules with the help of glycation reaction results in the formation of advanced glycation end products (AGEs). The formation of AGEs may activate receptors for advanced glycation end products which induce intracellular s...

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Autores principales:	Nayab Ishrat, Hamda Khan, Om P. S. Patel, Abbas Ali Mahdi, Farina Mujeeb, Saheem Ahmad
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/d63177ec7d4347f7af216b823fa3e0d7
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spelling	oai:doaj.org-article:d63177ec7d4347f7af216b823fa3e0d72021-11-08T02:37:14ZRole of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species2314-614110.1155/2021/7240046https://doaj.org/article/d63177ec7d4347f7af216b823fa3e0d72021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7240046https://doaj.org/toc/2314-6141The dysregulation of glucose metabolism that includes the modification of biomolecules with the help of glycation reaction results in the formation of advanced glycation end products (AGEs). The formation of AGEs may activate receptors for advanced glycation end products which induce intracellular signaling, ultimately enhancing oxidative stress, a well-known contributor to type 2 diabetes mellitus. In addition, AGEs are possible therapeutic targets for the treatment of type 2 diabetes mellitus and its complications. This review article highlights the antioxidant, anti-inflammatory, and antidiabetic properties of the Nymphaea species, and the screening of such aquatic plants for antiglycation activity may provide a safer alternative to the adverse effects related to glucotoxicity. Since oxidation and glycation are relatively similar to each other, therefore, there is a possibility that the Nymphaea species may also have antiglycating properties because of its powerful antioxidant properties. Herbal products and their derivatives are the preeminent resources showing prominent medicinal properties for most of the chronic diseases including type 2 diabetes mellitus. Among these, the Nymphaea species has also shown elevated activity in scavenging free radicals. This species has a load of phytochemical constituents which shows various therapeutic and nutritional value including anti-inflammatory and antioxidant profiles. To the best of our knowledge, this is the first article highlighting the possibility of an antiglycation value of the Nymphaea species by inhibiting AGEs in mediation of type 2 diabetes mellitus. We hope that in the next few years, the clinical and therapeutic potential may be explored and highlight a better perspective on the Nymphaea species in the inhibition of AGEs and its associated diseases such as type 2 diabetes mellitus.Nayab IshratHamda KhanOm P. S. PatelAbbas Ali MahdiFarina MujeebSaheem AhmadHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Nayab Ishrat Hamda Khan Om P. S. Patel Abbas Ali Mahdi Farina Mujeeb Saheem Ahmad Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species
description	The dysregulation of glucose metabolism that includes the modification of biomolecules with the help of glycation reaction results in the formation of advanced glycation end products (AGEs). The formation of AGEs may activate receptors for advanced glycation end products which induce intracellular signaling, ultimately enhancing oxidative stress, a well-known contributor to type 2 diabetes mellitus. In addition, AGEs are possible therapeutic targets for the treatment of type 2 diabetes mellitus and its complications. This review article highlights the antioxidant, anti-inflammatory, and antidiabetic properties of the Nymphaea species, and the screening of such aquatic plants for antiglycation activity may provide a safer alternative to the adverse effects related to glucotoxicity. Since oxidation and glycation are relatively similar to each other, therefore, there is a possibility that the Nymphaea species may also have antiglycating properties because of its powerful antioxidant properties. Herbal products and their derivatives are the preeminent resources showing prominent medicinal properties for most of the chronic diseases including type 2 diabetes mellitus. Among these, the Nymphaea species has also shown elevated activity in scavenging free radicals. This species has a load of phytochemical constituents which shows various therapeutic and nutritional value including anti-inflammatory and antioxidant profiles. To the best of our knowledge, this is the first article highlighting the possibility of an antiglycation value of the Nymphaea species by inhibiting AGEs in mediation of type 2 diabetes mellitus. We hope that in the next few years, the clinical and therapeutic potential may be explored and highlight a better perspective on the Nymphaea species in the inhibition of AGEs and its associated diseases such as type 2 diabetes mellitus.
format	article
author	Nayab Ishrat Hamda Khan Om P. S. Patel Abbas Ali Mahdi Farina Mujeeb Saheem Ahmad
author_facet	Nayab Ishrat Hamda Khan Om P. S. Patel Abbas Ali Mahdi Farina Mujeeb Saheem Ahmad
author_sort	Nayab Ishrat
title	Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species
title_short	Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species
title_full	Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species
title_fullStr	Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species
title_full_unstemmed	Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species
title_sort	role of glycation in type 2 diabetes mellitus and its prevention through nymphaea species
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d63177ec7d4347f7af216b823fa3e0d7
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Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species

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