Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.

<h4>Background</h4>The effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during functional endoscopic sinus surgery (FESS) is not clear yet. This study was conducted to answer this question.<h4>Methods</h4>This trial was conducted on 60 patients wi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Javaneh Jahanshahi, Farnaz Hashemian, Sara Pazira, Mohammad Hossein Bakhshaei, Farhad Farahani, Ruholah Abasi, Jalal Poorolajal
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d632ae67157f43648825fab602f39f14
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d632ae67157f43648825fab602f39f14
record_format	dspace
spelling	oai:doaj.org-article:d632ae67157f43648825fab602f39f142021-11-25T06:04:25ZEffect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.1932-620310.1371/journal.pone.0104477https://doaj.org/article/d632ae67157f43648825fab602f39f142014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0104477https://doaj.org/toc/1932-6203<h4>Background</h4>The effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during functional endoscopic sinus surgery (FESS) is not clear yet. This study was conducted to answer this question.<h4>Methods</h4>This trial was conducted on 60 patients with chronic sinusitis at Beasat Hospital, Hamadan, Iran, from April to November 2013. Thirty patients in the intervention group received three pledgets soaked with TXA 5% and phenylephrine 0.5% for 10 minutes in each nasal cavity before surgery. Thirty patients in the control group received phenylephrine 0.5% with the same way. The amount of bleeding and the quality of surgical field were evaluated at 15, 30, and 45 minutes after the start of surgery using Boezaart grading.<h4>Results</h4>The quality of the surgical field in the intervention group compared to the control group was significantly better in the first quarter (P = 0.002) and the second quarter (P = 0.003) but not in the third quarter (P = 0.163). Furthermore, the amount of bleeding was much less during all periods in the intervention group than in the control group (P = 0.001).<h4>Conclusion</h4>Topical TXA can efficiently reduce bleeding and improve the surgical field in FESS in patients with rhinosinusitis. Based on these findings, topical TXA may be a useful method for providing a suitable surgical field during the first 30 minutes after use.<h4>Trial registration</h4>Iranian Registry of Clinical Trials IRCT201212139014N15.Javaneh JahanshahiFarnaz HashemianSara PaziraMohammad Hossein BakhshaeiFarhad FarahaniRuholah AbasiJalal PoorolajalPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104477 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Javaneh Jahanshahi Farnaz Hashemian Sara Pazira Mohammad Hossein Bakhshaei Farhad Farahani Ruholah Abasi Jalal Poorolajal Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.
description	<h4>Background</h4>The effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during functional endoscopic sinus surgery (FESS) is not clear yet. This study was conducted to answer this question.<h4>Methods</h4>This trial was conducted on 60 patients with chronic sinusitis at Beasat Hospital, Hamadan, Iran, from April to November 2013. Thirty patients in the intervention group received three pledgets soaked with TXA 5% and phenylephrine 0.5% for 10 minutes in each nasal cavity before surgery. Thirty patients in the control group received phenylephrine 0.5% with the same way. The amount of bleeding and the quality of surgical field were evaluated at 15, 30, and 45 minutes after the start of surgery using Boezaart grading.<h4>Results</h4>The quality of the surgical field in the intervention group compared to the control group was significantly better in the first quarter (P = 0.002) and the second quarter (P = 0.003) but not in the third quarter (P = 0.163). Furthermore, the amount of bleeding was much less during all periods in the intervention group than in the control group (P = 0.001).<h4>Conclusion</h4>Topical TXA can efficiently reduce bleeding and improve the surgical field in FESS in patients with rhinosinusitis. Based on these findings, topical TXA may be a useful method for providing a suitable surgical field during the first 30 minutes after use.<h4>Trial registration</h4>Iranian Registry of Clinical Trials IRCT201212139014N15.
format	article
author	Javaneh Jahanshahi Farnaz Hashemian Sara Pazira Mohammad Hossein Bakhshaei Farhad Farahani Ruholah Abasi Jalal Poorolajal
author_facet	Javaneh Jahanshahi Farnaz Hashemian Sara Pazira Mohammad Hossein Bakhshaei Farhad Farahani Ruholah Abasi Jalal Poorolajal
author_sort	Javaneh Jahanshahi
title	Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.
title_short	Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.
title_full	Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.
title_fullStr	Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.
title_full_unstemmed	Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.
title_sort	effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d632ae67157f43648825fab602f39f14
work_keys_str_mv	AT javanehjahanshahi effectoftopicaltranexamicacidonbleedingandqualityofsurgicalfieldduringfunctionalendoscopicsinussurgeryinpatientswithchronicrhinosinusitisatripleblindrandomizedclinicaltrial AT farnazhashemian effectoftopicaltranexamicacidonbleedingandqualityofsurgicalfieldduringfunctionalendoscopicsinussurgeryinpatientswithchronicrhinosinusitisatripleblindrandomizedclinicaltrial AT sarapazira effectoftopicaltranexamicacidonbleedingandqualityofsurgicalfieldduringfunctionalendoscopicsinussurgeryinpatientswithchronicrhinosinusitisatripleblindrandomizedclinicaltrial AT mohammadhosseinbakhshaei effectoftopicaltranexamicacidonbleedingandqualityofsurgicalfieldduringfunctionalendoscopicsinussurgeryinpatientswithchronicrhinosinusitisatripleblindrandomizedclinicaltrial AT farhadfarahani effectoftopicaltranexamicacidonbleedingandqualityofsurgicalfieldduringfunctionalendoscopicsinussurgeryinpatientswithchronicrhinosinusitisatripleblindrandomizedclinicaltrial AT ruholahabasi effectoftopicaltranexamicacidonbleedingandqualityofsurgicalfieldduringfunctionalendoscopicsinussurgeryinpatientswithchronicrhinosinusitisatripleblindrandomizedclinicaltrial AT jalalpoorolajal effectoftopicaltranexamicacidonbleedingandqualityofsurgicalfieldduringfunctionalendoscopicsinussurgeryinpatientswithchronicrhinosinusitisatripleblindrandomizedclinicaltrial
_version_	1718414250103275520

Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial.

Ejemplares similares