Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure

Abstract Background Acute-on-chronic liver failure (ACLF) is a comprehensive syndrome characterized by an acute deterioration of liver function and high short-term mortality rates in patients with chronic liver disease. Whether plasma soluble urokinase plasminogen activator receptor (suPAR) is a sui...

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Autores principales:	Yunyun Wang, Fengtian Wu, Chao Chen, Lichen Xu, Wei Lin, Chunhong Huang, Ying Yang, Shanshan Wu, Jinjin Qi, Hanqin Cao, Guojun Li, Meng Hong, Haihong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	suPAR HBV ACLF Mortality ROS Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/d6334861d0cc4c188ebb36f5d6cf2ac6
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spelling	oai:doaj.org-article:d6334861d0cc4c188ebb36f5d6cf2ac62021-11-21T12:15:33ZSoluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure10.1186/s12876-021-02006-x1471-230Xhttps://doaj.org/article/d6334861d0cc4c188ebb36f5d6cf2ac62021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02006-xhttps://doaj.org/toc/1471-230XAbstract Background Acute-on-chronic liver failure (ACLF) is a comprehensive syndrome characterized by an acute deterioration of liver function and high short-term mortality rates in patients with chronic liver disease. Whether plasma soluble urokinase plasminogen activator receptor (suPAR) is a suitable biomarker for the prognosis of patients with ACLF remains unknown. Method A prospective cohort of 282 patients with ACLF from three hospitals in China was included. 88.4% of the group was hepatitis B virus-related ACLF (HBV-related ACLF). Cox regression was used to assess the impact of plasma suPAR and other factors on 30- and 90-day mortality. Reactive oxygen species (ROS) production were detected to explore the role of suPAR in regulating neutrophil function in HBV-related ACLF. Result There was no difference in plasma suPAR levels between HBV-related and non-HBV-related ACLF. Patients with clinical complications had higher suPAR levels than those without these complications. A significant correlation was also found between suPAR and prognostic scores, infection indicators and inflammatory cytokines. Cox’s regression multivariate analysis identified suPAR ≥ 14.7 ng/mL as a predictor for both day 30 and 90 mortality (Area under the ROC curve: 0.751 and 0.742 respectively), independent of the MELD and SOFA scores in patients with ACLF. Moreover, we firstly discovered suPAR enhanced neutrophil ROS production under E.coli stimulation in patients with HBV-related ACLF. Conclusions suPAR was a useful independent biomarker of short-term outcomes in patients with ACLF and might play a key role in the pathogenesis. Trial registration CNT, NCT02965560.Yunyun WangFengtian WuChao ChenLichen XuWei LinChunhong HuangYing YangShanshan WuJinjin QiHanqin CaoGuojun LiMeng HongHaihong ZhuBMCarticlesuPARHBVACLFMortalityROSDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	suPAR HBV ACLF Mortality ROS Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	suPAR HBV ACLF Mortality ROS Diseases of the digestive system. Gastroenterology RC799-869 Yunyun Wang Fengtian Wu Chao Chen Lichen Xu Wei Lin Chunhong Huang Ying Yang Shanshan Wu Jinjin Qi Hanqin Cao Guojun Li Meng Hong Haihong Zhu Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure
description	Abstract Background Acute-on-chronic liver failure (ACLF) is a comprehensive syndrome characterized by an acute deterioration of liver function and high short-term mortality rates in patients with chronic liver disease. Whether plasma soluble urokinase plasminogen activator receptor (suPAR) is a suitable biomarker for the prognosis of patients with ACLF remains unknown. Method A prospective cohort of 282 patients with ACLF from three hospitals in China was included. 88.4% of the group was hepatitis B virus-related ACLF (HBV-related ACLF). Cox regression was used to assess the impact of plasma suPAR and other factors on 30- and 90-day mortality. Reactive oxygen species (ROS) production were detected to explore the role of suPAR in regulating neutrophil function in HBV-related ACLF. Result There was no difference in plasma suPAR levels between HBV-related and non-HBV-related ACLF. Patients with clinical complications had higher suPAR levels than those without these complications. A significant correlation was also found between suPAR and prognostic scores, infection indicators and inflammatory cytokines. Cox’s regression multivariate analysis identified suPAR ≥ 14.7 ng/mL as a predictor for both day 30 and 90 mortality (Area under the ROC curve: 0.751 and 0.742 respectively), independent of the MELD and SOFA scores in patients with ACLF. Moreover, we firstly discovered suPAR enhanced neutrophil ROS production under E.coli stimulation in patients with HBV-related ACLF. Conclusions suPAR was a useful independent biomarker of short-term outcomes in patients with ACLF and might play a key role in the pathogenesis. Trial registration CNT, NCT02965560.
format	article
author	Yunyun Wang Fengtian Wu Chao Chen Lichen Xu Wei Lin Chunhong Huang Ying Yang Shanshan Wu Jinjin Qi Hanqin Cao Guojun Li Meng Hong Haihong Zhu
author_facet	Yunyun Wang Fengtian Wu Chao Chen Lichen Xu Wei Lin Chunhong Huang Ying Yang Shanshan Wu Jinjin Qi Hanqin Cao Guojun Li Meng Hong Haihong Zhu
author_sort	Yunyun Wang
title	Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure
title_short	Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure
title_full	Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure
title_fullStr	Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure
title_full_unstemmed	Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure
title_sort	soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d6334861d0cc4c188ebb36f5d6cf2ac6
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Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure

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