Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood

The activity of the RNA splicing factor MBNL1 is altered in myotonic dystrophy (DM) patients. Here the authors characterize the thymic phenotype of Mbnl1 knockout mice, including developmental defects, transcriptome changes, and RNA mis-splicing of transcripts encoding thymic transcription factors.

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Autores principales:	Łukasz J. Sznajder, Marina M. Scotti, Jihae Shin, Katarzyna Taylor, Franjo Ivankovic, Curtis A. Nutter, Faaiq N. Aslam, S. H. Subramony, Laura P. W. Ranum, Maurice S. Swanson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d633908c2a2e467aa55689a91243f33f
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spelling	oai:doaj.org-article:d633908c2a2e467aa55689a91243f33f2021-12-02T17:31:56ZLoss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood10.1038/s41467-020-15962-x2041-1723https://doaj.org/article/d633908c2a2e467aa55689a91243f33f2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15962-xhttps://doaj.org/toc/2041-1723The activity of the RNA splicing factor MBNL1 is altered in myotonic dystrophy (DM) patients. Here the authors characterize the thymic phenotype of Mbnl1 knockout mice, including developmental defects, transcriptome changes, and RNA mis-splicing of transcripts encoding thymic transcription factors.Łukasz J. SznajderMarina M. ScottiJihae ShinKatarzyna TaylorFranjo IvankovicCurtis A. NutterFaaiq N. AslamS. H. SubramonyLaura P. W. RanumMaurice S. SwansonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Łukasz J. Sznajder Marina M. Scotti Jihae Shin Katarzyna Taylor Franjo Ivankovic Curtis A. Nutter Faaiq N. Aslam S. H. Subramony Laura P. W. Ranum Maurice S. Swanson Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
description	The activity of the RNA splicing factor MBNL1 is altered in myotonic dystrophy (DM) patients. Here the authors characterize the thymic phenotype of Mbnl1 knockout mice, including developmental defects, transcriptome changes, and RNA mis-splicing of transcripts encoding thymic transcription factors.
format	article
author	Łukasz J. Sznajder Marina M. Scotti Jihae Shin Katarzyna Taylor Franjo Ivankovic Curtis A. Nutter Faaiq N. Aslam S. H. Subramony Laura P. W. Ranum Maurice S. Swanson
author_facet	Łukasz J. Sznajder Marina M. Scotti Jihae Shin Katarzyna Taylor Franjo Ivankovic Curtis A. Nutter Faaiq N. Aslam S. H. Subramony Laura P. W. Ranum Maurice S. Swanson
author_sort	Łukasz J. Sznajder
title	Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
title_short	Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
title_full	Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
title_fullStr	Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
title_full_unstemmed	Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
title_sort	loss of mbnl1 induces rna misprocessing in the thymus and peripheral blood
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d633908c2a2e467aa55689a91243f33f
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Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood

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