Rate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy

Background: Our study aimed to determine the correlation between the clinical staging of Fuchs' endothelial corneal dystrophy (FECD), rate of endothelial cell loss, and corneal biomechanical properties.Methods: This study combined a longitudinal retrospective/prospective analysis of corneal end...

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Autores principales:	Usanee Reinprayoon, Monthira Jermjutitham, Ngamjit Kasetsuwan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	FECD corneal biomechanics corvis fuchs' endothelial dystrophy corneal endothelial cell loss Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d63760280aa44f3184a190ade308b703
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spelling	oai:doaj.org-article:d63760280aa44f3184a190ade308b7032021-11-18T06:50:40ZRate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy2296-858X10.3389/fmed.2021.757959https://doaj.org/article/d63760280aa44f3184a190ade308b7032021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.757959/fullhttps://doaj.org/toc/2296-858XBackground: Our study aimed to determine the correlation between the clinical staging of Fuchs' endothelial corneal dystrophy (FECD), rate of endothelial cell loss, and corneal biomechanical properties.Methods: This study combined a longitudinal retrospective/prospective analysis of corneal endothelial cell loss and a prospective cross-sectional analysis of corneal biomechanics of Fuchs' endothelial dystrophy. The trial was registered at the Thai Clinical Trials Registry as TCTR 20160927004. FECD was diagnosed by the presence of corneal guttata detected by slit lamp microscopy; the disease severity was classified into four stages using the modified Stocker's classification. In vivo confocal microscopy, Scheimpflug imaging, and Corneal Visualization Scheimpflug Technology were performed to evaluate endothelial cell count, central corneal thickness, and corneal biomechanical properties. Linear mixed modeling analyses were used to estimate the endothelial cell densities in a 4-year period. The corneal biomechanics were compared among the stages using Corvis ST parameters.Results: Eighty eyes from eighty subjects were enrolled (42, 26, 12, and none in stages 1, 2, 3, and 4, respectively). The mean endothelial cell density was 1228.35 cells/mm2. The year-by-year reduction rate was 94.3 cells/mm2 (μEMM = −94.3, 95% CI: −115.4 to −73.2, p < 0.001). Corneal endothelial cell losses in Fuchs' endothelial dystrophy were estimated to be 7.7, 7.8, and 8.4% per year for stages 1, 2, and 3, respectively. The mean corneal thicknesses of stages 1, 2, and 3 were 556 ± 32, 623 ± 33, and 648 ± 50 mm, respectively. For the corneal biomechanical parameters, the A1-length and A1-time were significantly different between stages 1 and 3 (A1-length: mean diffstage1vs.3 = 0.10, 95% CI: < 0.001–0.15, p < 0.001, A1-time: mean diffstage1vs.3 = −0.24, 95% CI: −0.41 to −0.07, respectively).Conclusions: In the advanced stage, corneas significantly changed their biomechanical viscoelastic behavior by decreasing resistance, as measured by a longer A1-length and shorter A1-time.Usanee ReinprayoonUsanee ReinprayoonMonthira JermjutithamNgamjit KasetsuwanNgamjit KasetsuwanFrontiers Media S.A.articleFECDcorneal biomechanicscorvisfuchs' endothelial dystrophycorneal endothelial cell lossMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	FECD corneal biomechanics corvis fuchs' endothelial dystrophy corneal endothelial cell loss Medicine (General) R5-920
spellingShingle	FECD corneal biomechanics corvis fuchs' endothelial dystrophy corneal endothelial cell loss Medicine (General) R5-920 Usanee Reinprayoon Usanee Reinprayoon Monthira Jermjutitham Ngamjit Kasetsuwan Ngamjit Kasetsuwan Rate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy
description	Background: Our study aimed to determine the correlation between the clinical staging of Fuchs' endothelial corneal dystrophy (FECD), rate of endothelial cell loss, and corneal biomechanical properties.Methods: This study combined a longitudinal retrospective/prospective analysis of corneal endothelial cell loss and a prospective cross-sectional analysis of corneal biomechanics of Fuchs' endothelial dystrophy. The trial was registered at the Thai Clinical Trials Registry as TCTR 20160927004. FECD was diagnosed by the presence of corneal guttata detected by slit lamp microscopy; the disease severity was classified into four stages using the modified Stocker's classification. In vivo confocal microscopy, Scheimpflug imaging, and Corneal Visualization Scheimpflug Technology were performed to evaluate endothelial cell count, central corneal thickness, and corneal biomechanical properties. Linear mixed modeling analyses were used to estimate the endothelial cell densities in a 4-year period. The corneal biomechanics were compared among the stages using Corvis ST parameters.Results: Eighty eyes from eighty subjects were enrolled (42, 26, 12, and none in stages 1, 2, 3, and 4, respectively). The mean endothelial cell density was 1228.35 cells/mm2. The year-by-year reduction rate was 94.3 cells/mm2 (μEMM = −94.3, 95% CI: −115.4 to −73.2, p < 0.001). Corneal endothelial cell losses in Fuchs' endothelial dystrophy were estimated to be 7.7, 7.8, and 8.4% per year for stages 1, 2, and 3, respectively. The mean corneal thicknesses of stages 1, 2, and 3 were 556 ± 32, 623 ± 33, and 648 ± 50 mm, respectively. For the corneal biomechanical parameters, the A1-length and A1-time were significantly different between stages 1 and 3 (A1-length: mean diffstage1vs.3 = 0.10, 95% CI: < 0.001–0.15, p < 0.001, A1-time: mean diffstage1vs.3 = −0.24, 95% CI: −0.41 to −0.07, respectively).Conclusions: In the advanced stage, corneas significantly changed their biomechanical viscoelastic behavior by decreasing resistance, as measured by a longer A1-length and shorter A1-time.
format	article
author	Usanee Reinprayoon Usanee Reinprayoon Monthira Jermjutitham Ngamjit Kasetsuwan Ngamjit Kasetsuwan
author_facet	Usanee Reinprayoon Usanee Reinprayoon Monthira Jermjutitham Ngamjit Kasetsuwan Ngamjit Kasetsuwan
author_sort	Usanee Reinprayoon
title	Rate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy
title_short	Rate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy
title_full	Rate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy
title_fullStr	Rate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy
title_full_unstemmed	Rate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy
title_sort	rate of cornea endothelial cell loss and biomechanical properties in fuchs' endothelial corneal dystrophy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d63760280aa44f3184a190ade308b703
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_version_	1718424321951531008

Rate of Cornea Endothelial Cell Loss and Biomechanical Properties in Fuchs' Endothelial Corneal Dystrophy

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