The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans

Abstract Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christopher J. Esh, Bryna C. R. Chrismas, Alexis R. Mauger, Anissa Cherif, John Molphy, Lee Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d637c315d0a24df283ce547efc38906f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d637c315d0a24df283ce547efc38906f
record_format	dspace
spelling	oai:doaj.org-article:d637c315d0a24df283ce547efc38906f2021-12-02T16:35:56ZThe influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans10.1038/s41598-021-84563-52045-2322https://doaj.org/article/d637c315d0a24df283ce547efc38906f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84563-5https://doaj.org/toc/2045-2322Abstract Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4–1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [− 0.5 (− 0.8 to − 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (− 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.Christopher J. EshBryna C. R. ChrismasAlexis R. MaugerAnissa CherifJohn MolphyLee TaylorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christopher J. Esh Bryna C. R. Chrismas Alexis R. Mauger Anissa Cherif John Molphy Lee Taylor The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans
description	Abstract Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4–1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [− 0.5 (− 0.8 to − 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (− 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.
format	article
author	Christopher J. Esh Bryna C. R. Chrismas Alexis R. Mauger Anissa Cherif John Molphy Lee Taylor
author_facet	Christopher J. Esh Bryna C. R. Chrismas Alexis R. Mauger Anissa Cherif John Molphy Lee Taylor
author_sort	Christopher J. Esh
title	The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans
title_short	The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans
title_full	The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans
title_fullStr	The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans
title_full_unstemmed	The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans
title_sort	influence of environmental and core temperature on cyclooxygenase and pge2 in healthy humans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d637c315d0a24df283ce547efc38906f
work_keys_str_mv	AT christopherjesh theinfluenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT brynacrchrismas theinfluenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT alexisrmauger theinfluenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT anissacherif theinfluenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT johnmolphy theinfluenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT leetaylor theinfluenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT christopherjesh influenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT brynacrchrismas influenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT alexisrmauger influenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT anissacherif influenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT johnmolphy influenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans AT leetaylor influenceofenvironmentalandcoretemperatureoncyclooxygenaseandpge2inhealthyhumans
_version_	1718383721722150912

The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans

Ejemplares similares