Encoding of acquired sound-sequence salience by auditory cortical offset responses

Summary: Behaviorally relevant sounds are often composed of distinct acoustic units organized into specific temporal sequences. The meaning of such sound sequences can therefore be fully recognized only when they have terminated. However, the neural mechanisms underlying the perception of sound sequ...

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Autores principales:	Joonyeup Lee, Gideon Rothschild
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	auditory cortex off responses sound sequences learning neural coding two-photon imaging Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d63e56ce27f34498a5a239612fd7c2b9
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spelling	oai:doaj.org-article:d63e56ce27f34498a5a239612fd7c2b92021-11-04T04:29:16ZEncoding of acquired sound-sequence salience by auditory cortical offset responses2211-124710.1016/j.celrep.2021.109927https://doaj.org/article/d63e56ce27f34498a5a239612fd7c2b92021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721014005https://doaj.org/toc/2211-1247Summary: Behaviorally relevant sounds are often composed of distinct acoustic units organized into specific temporal sequences. The meaning of such sound sequences can therefore be fully recognized only when they have terminated. However, the neural mechanisms underlying the perception of sound sequences remain unclear. Here, we use two-photon calcium imaging in the auditory cortex of behaving mice to test the hypothesis that neural responses to termination of sound sequences (“Off-responses”) encode their acoustic history and behavioral salience. We find that auditory cortical Off-responses encode preceding sound sequences and that learning to associate a sound sequence with a reward induces enhancement of Off-responses relative to responses during the sound sequence (“On-responses”). Furthermore, learning enhances network-level discriminability of sound sequences by Off-responses. Last, learning-induced plasticity of Off-responses but not On-responses lasts to the next day. These findings identify auditory cortical Off-responses as a key neural signature of acquired sound-sequence salience.Joonyeup LeeGideon RothschildElsevierarticleauditory cortexoff responsessound sequenceslearningneural codingtwo-photon imagingBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 5, Pp 109927- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	auditory cortex off responses sound sequences learning neural coding two-photon imaging Biology (General) QH301-705.5
spellingShingle	auditory cortex off responses sound sequences learning neural coding two-photon imaging Biology (General) QH301-705.5 Joonyeup Lee Gideon Rothschild Encoding of acquired sound-sequence salience by auditory cortical offset responses
description	Summary: Behaviorally relevant sounds are often composed of distinct acoustic units organized into specific temporal sequences. The meaning of such sound sequences can therefore be fully recognized only when they have terminated. However, the neural mechanisms underlying the perception of sound sequences remain unclear. Here, we use two-photon calcium imaging in the auditory cortex of behaving mice to test the hypothesis that neural responses to termination of sound sequences (“Off-responses”) encode their acoustic history and behavioral salience. We find that auditory cortical Off-responses encode preceding sound sequences and that learning to associate a sound sequence with a reward induces enhancement of Off-responses relative to responses during the sound sequence (“On-responses”). Furthermore, learning enhances network-level discriminability of sound sequences by Off-responses. Last, learning-induced plasticity of Off-responses but not On-responses lasts to the next day. These findings identify auditory cortical Off-responses as a key neural signature of acquired sound-sequence salience.
format	article
author	Joonyeup Lee Gideon Rothschild
author_facet	Joonyeup Lee Gideon Rothschild
author_sort	Joonyeup Lee
title	Encoding of acquired sound-sequence salience by auditory cortical offset responses
title_short	Encoding of acquired sound-sequence salience by auditory cortical offset responses
title_full	Encoding of acquired sound-sequence salience by auditory cortical offset responses
title_fullStr	Encoding of acquired sound-sequence salience by auditory cortical offset responses
title_full_unstemmed	Encoding of acquired sound-sequence salience by auditory cortical offset responses
title_sort	encoding of acquired sound-sequence salience by auditory cortical offset responses
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d63e56ce27f34498a5a239612fd7c2b9
work_keys_str_mv	AT joonyeuplee encodingofacquiredsoundsequencesaliencebyauditorycorticaloffsetresponses AT gideonrothschild encodingofacquiredsoundsequencesaliencebyauditorycorticaloffsetresponses
_version_	1718445302837411840

Encoding of acquired sound-sequence salience by auditory cortical offset responses

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