Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum

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Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum

Decreased susceptibilities of the human malaria parasite Plasmodium falciparum towards the endoperoxide antimalarial artemisinin are linked to mutations of residue C580 of PfKelch13, a homologue of the redox sensor Keap1 and other vertebrate BTB-Kelch proteins. Here, we addressed whether mutations a...

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Autores principales:	Robin Schumann, Eileen Bischoff, Severina Klaus, Sophie Möhring, Julia Flock, Sandro Keller, Kim Remans, Markus Ganter, Marcel Deponte
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Malaria Artemisinin Keap1 Kelch13 Protein folding Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d643779b262a4fcd8ac0dc6cb6438b67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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