High association of COVID-19 severity with poor gut health score in Lebanese patients.

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme challenges for developing countries that are experiencing economic crises. Studies on COVID-19 symptoms and gut health are scarce and have not f...

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Autores principales:	Imad Al Kassaa, Sarah El Omari, Nada Abbas, Nicolas Papon, Djamel Drider, Issmat I Kassem, Marwan Osman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6448e246eb84b83b375bcdffcf81a49
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spelling	oai:doaj.org-article:d6448e246eb84b83b375bcdffcf81a492021-12-02T20:07:48ZHigh association of COVID-19 severity with poor gut health score in Lebanese patients.1932-620310.1371/journal.pone.0258913https://doaj.org/article/d6448e246eb84b83b375bcdffcf81a492021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258913https://doaj.org/toc/1932-6203<h4>Background</h4>Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme challenges for developing countries that are experiencing economic crises. Studies on COVID-19 symptoms and gut health are scarce and have not fully analyzed possible associations between gut health and disease pathophysiology. Therefore, this study aimed to demonstrate a potential association between gut health and COVID-19 severity in the Lebanese community, which has been experiencing a severe economic crisis.<h4>Methods</h4>This cross-sectional study investigated SARS-CoV-2 PCR-positive Lebanese patients. Participants were interviewed and gut health, COVID-19 symptoms, and different metrics were analyzed using simple and multiple logistic regression models.<h4>Results</h4>Analysis of the data showed that 25% of participants were asymptomatic, while an equal proportion experienced severe symptoms, including dyspnea (22.7%), oxygen need (7.5%), and hospitalization (3.1%). The mean age of the participants was 38.3 ±0.8 years, and the majority were males (63.9%), married (68.2%), and currently employed (66.7%). A negative correlation was found between gut health score and COVID-19 symptoms (Kendall's tau-b = -0.153, P = 0.004); indicating that low gut health was associated with more severe COVID-19 cases. Additionally, participants who reported unhealthy food intake were more likely to experience severe symptoms (Kendall's tau-b = 0.118, P = 0.049). When all items were taken into consideration, multiple ordinal logistic regression models showed a significant association between COVID-19 symptoms and each of the following variables: working status, flu-like illness episodes, and gut health score. COVID-19 severe symptoms were more common among patients having poor gut health scores (OR:1.31, 95%CI:1.07-1.61; P = 0.008), experiencing more than one episode of flu-like illness per year (OR:2.85, 95%CI:1.58-5.15; P = 0.001), and owning a job (OR:2.00, 95%CI:1.1-3.65; P = 0.023).<h4>Conclusions</h4>To our knowledge, this is the first study that showed the impact of gut health and exposure to respiratory viruses on COVID-19 severity in Lebanon. These findings can facilitate combating the pandemic in Lebanon.Imad Al KassaaSarah El OmariNada AbbasNicolas PaponDjamel DriderIssmat I KassemMarwan OsmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258913 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Imad Al Kassaa Sarah El Omari Nada Abbas Nicolas Papon Djamel Drider Issmat I Kassem Marwan Osman High association of COVID-19 severity with poor gut health score in Lebanese patients.
description	<h4>Background</h4>Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme challenges for developing countries that are experiencing economic crises. Studies on COVID-19 symptoms and gut health are scarce and have not fully analyzed possible associations between gut health and disease pathophysiology. Therefore, this study aimed to demonstrate a potential association between gut health and COVID-19 severity in the Lebanese community, which has been experiencing a severe economic crisis.<h4>Methods</h4>This cross-sectional study investigated SARS-CoV-2 PCR-positive Lebanese patients. Participants were interviewed and gut health, COVID-19 symptoms, and different metrics were analyzed using simple and multiple logistic regression models.<h4>Results</h4>Analysis of the data showed that 25% of participants were asymptomatic, while an equal proportion experienced severe symptoms, including dyspnea (22.7%), oxygen need (7.5%), and hospitalization (3.1%). The mean age of the participants was 38.3 ±0.8 years, and the majority were males (63.9%), married (68.2%), and currently employed (66.7%). A negative correlation was found between gut health score and COVID-19 symptoms (Kendall's tau-b = -0.153, P = 0.004); indicating that low gut health was associated with more severe COVID-19 cases. Additionally, participants who reported unhealthy food intake were more likely to experience severe symptoms (Kendall's tau-b = 0.118, P = 0.049). When all items were taken into consideration, multiple ordinal logistic regression models showed a significant association between COVID-19 symptoms and each of the following variables: working status, flu-like illness episodes, and gut health score. COVID-19 severe symptoms were more common among patients having poor gut health scores (OR:1.31, 95%CI:1.07-1.61; P = 0.008), experiencing more than one episode of flu-like illness per year (OR:2.85, 95%CI:1.58-5.15; P = 0.001), and owning a job (OR:2.00, 95%CI:1.1-3.65; P = 0.023).<h4>Conclusions</h4>To our knowledge, this is the first study that showed the impact of gut health and exposure to respiratory viruses on COVID-19 severity in Lebanon. These findings can facilitate combating the pandemic in Lebanon.
format	article
author	Imad Al Kassaa Sarah El Omari Nada Abbas Nicolas Papon Djamel Drider Issmat I Kassem Marwan Osman
author_facet	Imad Al Kassaa Sarah El Omari Nada Abbas Nicolas Papon Djamel Drider Issmat I Kassem Marwan Osman
author_sort	Imad Al Kassaa
title	High association of COVID-19 severity with poor gut health score in Lebanese patients.
title_short	High association of COVID-19 severity with poor gut health score in Lebanese patients.
title_full	High association of COVID-19 severity with poor gut health score in Lebanese patients.
title_fullStr	High association of COVID-19 severity with poor gut health score in Lebanese patients.
title_full_unstemmed	High association of COVID-19 severity with poor gut health score in Lebanese patients.
title_sort	high association of covid-19 severity with poor gut health score in lebanese patients.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d6448e246eb84b83b375bcdffcf81a49
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High association of COVID-19 severity with poor gut health score in Lebanese patients.

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