The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation

Huaiji Wang,1 Jie Zang,2 Zihan Zhao,3 Qin Zhang,1 Shunjie Chen1 1Department of Nephrology, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji Universi...

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Autores principales:	Wang H, Zang J, Zhao Z, Zhang Q, Chen S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	neutrophil-derived delivery tumors and inflammation targeting circulation biostability Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d644fd62d9f341e08410ebca7d0a2b8d
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spelling	oai:doaj.org-article:d644fd62d9f341e08410ebca7d0a2b8d2021-12-02T18:43:43ZThe Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation1178-2013https://doaj.org/article/d644fd62d9f341e08410ebca7d0a2b8d2021-11-01T00:00:00Zhttps://www.dovepress.com/the-advances-of-neutrophil-derived-effective-drug-delivery-systems-a-k-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Huaiji Wang,1 Jie Zang,2 Zihan Zhao,3 Qin Zhang,1 Shunjie Chen1 1Department of Nephrology, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 3Department of Dermatology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of ChinaCorrespondence: Shunjie ChenDepartment of Nephrology, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of ChinaEmail chenshunjie77csj@163.comAbstract: The chimeric trait of recruitment by inflammatory signals endows neutrophils with the functionality of migrating to inflamed tissues, which can be utilized to tailor novel drug delivery systems. In this review, we introduce a mechanism of neutrophil-derived drug delivery systems recruited into inflamed sites and provide insight into tumors and inflammation therapy. In particular, the advantages of neutrophils—their endogenous-derived neutrophil membrane, exosomes as drug carriers for augmented targeting, prolonged circulation, and improved biostability—were concluded. Subsequently, the latest application in the treatment of tumors and inflammation was elaborated upon, followed by a discussion of the future prospects to neutrophil-derived delivery systems. This promising system will provide new therapeutic avenues for the treatment of inflammation and tumors.Keywords: neutrophil-derived delivery, tumors and inflammation, targeting, circulation, biostabilityWang HZang JZhao ZZhang QChen SDove Medical Pressarticleneutrophil-derived deliverytumors and inflammationtargetingcirculationbiostabilityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 7663-7681 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophil-derived delivery tumors and inflammation targeting circulation biostability Medicine (General) R5-920
spellingShingle	neutrophil-derived delivery tumors and inflammation targeting circulation biostability Medicine (General) R5-920 Wang H Zang J Zhao Z Zhang Q Chen S The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation
description	Huaiji Wang,1 Jie Zang,2 Zihan Zhao,3 Qin Zhang,1 Shunjie Chen1 1Department of Nephrology, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 3Department of Dermatology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of ChinaCorrespondence: Shunjie ChenDepartment of Nephrology, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of ChinaEmail chenshunjie77csj@163.comAbstract: The chimeric trait of recruitment by inflammatory signals endows neutrophils with the functionality of migrating to inflamed tissues, which can be utilized to tailor novel drug delivery systems. In this review, we introduce a mechanism of neutrophil-derived drug delivery systems recruited into inflamed sites and provide insight into tumors and inflammation therapy. In particular, the advantages of neutrophils—their endogenous-derived neutrophil membrane, exosomes as drug carriers for augmented targeting, prolonged circulation, and improved biostability—were concluded. Subsequently, the latest application in the treatment of tumors and inflammation was elaborated upon, followed by a discussion of the future prospects to neutrophil-derived delivery systems. This promising system will provide new therapeutic avenues for the treatment of inflammation and tumors.Keywords: neutrophil-derived delivery, tumors and inflammation, targeting, circulation, biostability
format	article
author	Wang H Zang J Zhao Z Zhang Q Chen S
author_facet	Wang H Zang J Zhao Z Zhang Q Chen S
author_sort	Wang H
title	The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation
title_short	The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation
title_full	The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation
title_fullStr	The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation
title_full_unstemmed	The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation
title_sort	advances of neutrophil-derived effective drug delivery systems: a key review of managing tumors and inflammation
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d644fd62d9f341e08410ebca7d0a2b8d
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The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation

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