Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.

<h4>Background</h4>Susceptibility to viral infections as well as their severity are higher in men than in women. Heightened antiviral responses typical of women are effective for rapid virus clearance, but if excessively high or prolonged, can result in chronic/inflammatory pathologies....

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Autores principales:	Maria Gabriella Torcia, Lucia Nencioni, Ann Maria Clemente, Livia Civitelli, Ignacio Celestino, Dolores Limongi, Giulia Fadigati, Eloisa Perissi, Federico Cozzolino, Enrico Garaci, Anna Teresa Palamara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6457b53078b4b27adaef4ba21d1bbeb
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spelling	oai:doaj.org-article:d6457b53078b4b27adaef4ba21d1bbeb2021-11-18T07:13:52ZSex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.1932-620310.1371/journal.pone.0039853https://doaj.org/article/d6457b53078b4b27adaef4ba21d1bbeb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22768144/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Susceptibility to viral infections as well as their severity are higher in men than in women. Heightened antiviral responses typical of women are effective for rapid virus clearance, but if excessively high or prolonged, can result in chronic/inflammatory pathologies. We investigated whether this variability could be in part attributable to differences in the response to the Toll-Like Receptors (TLR) more involved in the virus recognition.<h4>Methods</h4>Cytokine production by peripheral blood mononuclear cells (PBMCs) from male and female healthy donors after stimulation with Toll-like receptors (TLR) 3, 7, 8, 9 ligands or with viruses (influenza and Herpes-simplex-1) was evaluated.<h4>Results</h4>Compared to females, PBMCs from males produced not only lower amounts of IFN-α in response to TLR7 ligands but also higher amounts of the immunosuppressive cytokine IL10 after stimulation with TLR8 and TLR9 ligands or viruses. IL10 production after TLR9 ligands or HSV-1 stimulation was significantly related with plasma levels of sex hormones in both groups, whereas no correlation was found in cytokines produced following TLR7 and TLR8 stimulation.<h4>Conclusions</h4>Given the role of an early production of IL10 by cells of innate immunity in modulating innate and adaptive immune response to viruses, we suggest that sex-related difference in its production following viral nucleic acid stimulation of TLRs may be involved in the sex-related variability in response to viral infections.Maria Gabriella TorciaLucia NencioniAnn Maria ClementeLivia CivitelliIgnacio CelestinoDolores LimongiGiulia FadigatiEloisa PerissiFederico CozzolinoEnrico GaraciAnna Teresa PalamaraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39853 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Gabriella Torcia Lucia Nencioni Ann Maria Clemente Livia Civitelli Ignacio Celestino Dolores Limongi Giulia Fadigati Eloisa Perissi Federico Cozzolino Enrico Garaci Anna Teresa Palamara Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.
description	<h4>Background</h4>Susceptibility to viral infections as well as their severity are higher in men than in women. Heightened antiviral responses typical of women are effective for rapid virus clearance, but if excessively high or prolonged, can result in chronic/inflammatory pathologies. We investigated whether this variability could be in part attributable to differences in the response to the Toll-Like Receptors (TLR) more involved in the virus recognition.<h4>Methods</h4>Cytokine production by peripheral blood mononuclear cells (PBMCs) from male and female healthy donors after stimulation with Toll-like receptors (TLR) 3, 7, 8, 9 ligands or with viruses (influenza and Herpes-simplex-1) was evaluated.<h4>Results</h4>Compared to females, PBMCs from males produced not only lower amounts of IFN-α in response to TLR7 ligands but also higher amounts of the immunosuppressive cytokine IL10 after stimulation with TLR8 and TLR9 ligands or viruses. IL10 production after TLR9 ligands or HSV-1 stimulation was significantly related with plasma levels of sex hormones in both groups, whereas no correlation was found in cytokines produced following TLR7 and TLR8 stimulation.<h4>Conclusions</h4>Given the role of an early production of IL10 by cells of innate immunity in modulating innate and adaptive immune response to viruses, we suggest that sex-related difference in its production following viral nucleic acid stimulation of TLRs may be involved in the sex-related variability in response to viral infections.
format	article
author	Maria Gabriella Torcia Lucia Nencioni Ann Maria Clemente Livia Civitelli Ignacio Celestino Dolores Limongi Giulia Fadigati Eloisa Perissi Federico Cozzolino Enrico Garaci Anna Teresa Palamara
author_facet	Maria Gabriella Torcia Lucia Nencioni Ann Maria Clemente Livia Civitelli Ignacio Celestino Dolores Limongi Giulia Fadigati Eloisa Perissi Federico Cozzolino Enrico Garaci Anna Teresa Palamara
author_sort	Maria Gabriella Torcia
title	Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.
title_short	Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.
title_full	Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.
title_fullStr	Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.
title_full_unstemmed	Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.
title_sort	sex differences in the response to viral infections: tlr8 and tlr9 ligand stimulation induce higher il10 production in males.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d6457b53078b4b27adaef4ba21d1bbeb
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Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males.

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