Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells

Alterations in metabolism and amino acid usage are common in cancer cells. Here, the authors show in prostate cancer cells that arginine globally upregulates nuclear-encoded oxidative phosphorylation genes by altering histone acetylation and retaining TEAD4 in the nucleus to transactivate genes.

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Autores principales:	Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen, Hsing-Jien Kung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d64749011def4c1eae0aaa79e53f01e3
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spelling	oai:doaj.org-article:d64749011def4c1eae0aaa79e53f01e32021-12-02T17:33:34ZArginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells10.1038/s41467-021-22652-92041-1723https://doaj.org/article/d64749011def4c1eae0aaa79e53f01e32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22652-9https://doaj.org/toc/2041-1723Alterations in metabolism and amino acid usage are common in cancer cells. Here, the authors show in prostate cancer cells that arginine globally upregulates nuclear-encoded oxidative phosphorylation genes by altering histone acetylation and retaining TEAD4 in the nucleus to transactivate genes.Chia-Lin ChenSheng-Chieh HsuTan-Ya ChungCheng-Ying ChuHung-Jung WangPei-Wen HsiaoShauh-Der YehDavid K. AnnYun YenHsing-Jien KungNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chia-Lin Chen Sheng-Chieh Hsu Tan-Ya Chung Cheng-Ying Chu Hung-Jung Wang Pei-Wen Hsiao Shauh-Der Yeh David K. Ann Yun Yen Hsing-Jien Kung Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
description	Alterations in metabolism and amino acid usage are common in cancer cells. Here, the authors show in prostate cancer cells that arginine globally upregulates nuclear-encoded oxidative phosphorylation genes by altering histone acetylation and retaining TEAD4 in the nucleus to transactivate genes.
format	article
author	Chia-Lin Chen Sheng-Chieh Hsu Tan-Ya Chung Cheng-Ying Chu Hung-Jung Wang Pei-Wen Hsiao Shauh-Der Yeh David K. Ann Yun Yen Hsing-Jien Kung
author_facet	Chia-Lin Chen Sheng-Chieh Hsu Tan-Ya Chung Cheng-Ying Chu Hung-Jung Wang Pei-Wen Hsiao Shauh-Der Yeh David K. Ann Yun Yen Hsing-Jien Kung
author_sort	Chia-Lin Chen
title	Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
title_short	Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
title_full	Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
title_fullStr	Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
title_full_unstemmed	Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
title_sort	arginine is an epigenetic regulator targeting tead4 to modulate oxphos in prostate cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d64749011def4c1eae0aaa79e53f01e3
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Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells

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