Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

Removal of the C. elegans germline substantially increases organismal lifespan. Here, Nakamura et al. show that the transcription factors MML-1 and MXL-2 coordinate this process in that they reduce TOR signalling and increase autophagy by regulating activity of HLH-30.

Guardado en:

Detalles Bibliográficos
Autores principales:	Shuhei Nakamura, Özlem Karalay, Philipp S. Jäger, Makoto Horikawa, Corinna Klein, Kayo Nakamura, Christian Latza, Sven E. Templer, Christoph Dieterich, Adam Antebi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d64ac3f9db434a949312fa7d63fb441c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d64ac3f9db434a949312fa7d63fb441c
record_format	dspace
spelling	oai:doaj.org-article:d64ac3f9db434a949312fa7d63fb441c2021-12-02T14:38:55ZMondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals10.1038/ncomms109442041-1723https://doaj.org/article/d64ac3f9db434a949312fa7d63fb441c2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10944https://doaj.org/toc/2041-1723Removal of the C. elegans germline substantially increases organismal lifespan. Here, Nakamura et al. show that the transcription factors MML-1 and MXL-2 coordinate this process in that they reduce TOR signalling and increase autophagy by regulating activity of HLH-30.Shuhei NakamuraÖzlem KaralayPhilipp S. JägerMakoto HorikawaCorinna KleinKayo NakamuraChristian LatzaSven E. TemplerChristoph DieterichAdam AntebiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuhei Nakamura Özlem Karalay Philipp S. Jäger Makoto Horikawa Corinna Klein Kayo Nakamura Christian Latza Sven E. Templer Christoph Dieterich Adam Antebi Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
description	Removal of the C. elegans germline substantially increases organismal lifespan. Here, Nakamura et al. show that the transcription factors MML-1 and MXL-2 coordinate this process in that they reduce TOR signalling and increase autophagy by regulating activity of HLH-30.
format	article
author	Shuhei Nakamura Özlem Karalay Philipp S. Jäger Makoto Horikawa Corinna Klein Kayo Nakamura Christian Latza Sven E. Templer Christoph Dieterich Adam Antebi
author_facet	Shuhei Nakamura Özlem Karalay Philipp S. Jäger Makoto Horikawa Corinna Klein Kayo Nakamura Christian Latza Sven E. Templer Christoph Dieterich Adam Antebi
author_sort	Shuhei Nakamura
title	Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
title_short	Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
title_full	Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
title_fullStr	Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
title_full_unstemmed	Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
title_sort	mondo complexes regulate tfeb via tor inhibition to promote longevity in response to gonadal signals
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d64ac3f9db434a949312fa7d63fb441c
work_keys_str_mv	AT shuheinakamura mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals AT ozlemkaralay mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals AT philippsjager mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals AT makotohorikawa mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals AT corinnaklein mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals AT kayonakamura mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals AT christianlatza mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals AT svenetempler mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals AT christophdieterich mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals AT adamantebi mondocomplexesregulatetfebviatorinhibitiontopromotelongevityinresponsetogonadalsignals
_version_	1718390800203644928

Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

Ejemplares similares