αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development

It is unclear which signals regulate the establishment of the tooth signalling centre, the enamel knot (EK). Here, the authors show that EK formation depends on αE-catenin, which acts to restrict the Hippo pathway transcription factors Yes-associated protein (YAP) and TAZ.

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Autores principales:	Chun-Ying Li, Jimmy Hu, Hongbing Lu, Jing Lan, Wei Du, Nicole Galicia, Ophir D. Klein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d64ac56e33ff4303bea39c5f99d644e9
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spelling	oai:doaj.org-article:d64ac56e33ff4303bea39c5f99d644e92021-12-02T15:34:58ZαE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development10.1038/ncomms121332041-1723https://doaj.org/article/d64ac56e33ff4303bea39c5f99d644e92016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12133https://doaj.org/toc/2041-1723It is unclear which signals regulate the establishment of the tooth signalling centre, the enamel knot (EK). Here, the authors show that EK formation depends on αE-catenin, which acts to restrict the Hippo pathway transcription factors Yes-associated protein (YAP) and TAZ.Chun-Ying LiJimmy HuHongbing LuJing LanWei DuNicole GaliciaOphir D. KleinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chun-Ying Li Jimmy Hu Hongbing Lu Jing Lan Wei Du Nicole Galicia Ophir D. Klein αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
description	It is unclear which signals regulate the establishment of the tooth signalling centre, the enamel knot (EK). Here, the authors show that EK formation depends on αE-catenin, which acts to restrict the Hippo pathway transcription factors Yes-associated protein (YAP) and TAZ.
format	article
author	Chun-Ying Li Jimmy Hu Hongbing Lu Jing Lan Wei Du Nicole Galicia Ophir D. Klein
author_facet	Chun-Ying Li Jimmy Hu Hongbing Lu Jing Lan Wei Du Nicole Galicia Ophir D. Klein
author_sort	Chun-Ying Li
title	αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_short	αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_full	αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_fullStr	αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_full_unstemmed	αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
title_sort	αe-catenin inhibits yap/taz activity to regulate signalling centre formation during tooth development
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d64ac56e33ff4303bea39c5f99d644e9
work_keys_str_mv	AT chunyingli aecatenininhibitsyaptazactivitytoregulatesignallingcentreformationduringtoothdevelopment AT jimmyhu aecatenininhibitsyaptazactivitytoregulatesignallingcentreformationduringtoothdevelopment AT hongbinglu aecatenininhibitsyaptazactivitytoregulatesignallingcentreformationduringtoothdevelopment AT jinglan aecatenininhibitsyaptazactivitytoregulatesignallingcentreformationduringtoothdevelopment AT weidu aecatenininhibitsyaptazactivitytoregulatesignallingcentreformationduringtoothdevelopment AT nicolegalicia aecatenininhibitsyaptazactivitytoregulatesignallingcentreformationduringtoothdevelopment AT ophirdklein aecatenininhibitsyaptazactivitytoregulatesignallingcentreformationduringtoothdevelopment
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αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development

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