A Common Food Glycan, Pectin, Shares an Antigen with <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Capsule

ABSTRACT We are exposed daily to many glycans from bacteria and food plants. Bacterial glycans are generally antigenic and elicit antibody responses. It is unclear if food glycans’ sharing of antigens with bacterial glycans influences our immune responses to bacteria. We studied 14 different plant f...

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Autores principales:	Moon H. Nahm, Jigui Yu, Jiri Vlach, Maor Bar-Peled
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	food bacteria vaccine polysaccharide Streptococcus pneumoniae capsule Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d64b9d1ae2864738a32cbe4a6d28c23d
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spelling	oai:doaj.org-article:d64b9d1ae2864738a32cbe4a6d28c23d2021-11-15T15:29:16ZA Common Food Glycan, Pectin, Shares an Antigen with <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Capsule10.1128/mSphere.00074-202379-5042https://doaj.org/article/d64b9d1ae2864738a32cbe4a6d28c23d2020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00074-20https://doaj.org/toc/2379-5042ABSTRACT We are exposed daily to many glycans from bacteria and food plants. Bacterial glycans are generally antigenic and elicit antibody responses. It is unclear if food glycans’ sharing of antigens with bacterial glycans influences our immune responses to bacteria. We studied 14 different plant foods for cross-reactivity with monoclonal antibodies (MAbs) against 24 pneumococcal serotypes which commonly cause infections and are included in pneumococcal vaccines. Serotype 15B-specific MAb cross-reacts with fruit peels, and serotype 10A MAb cross-reacts with many natural and processed plant foods. The serotype 10A cross-reactive epitope is 1,6-β-galactosidase [βGal(1-6)], present in the rhamno-galacturonan I (RG-I) domain of pectin. Despite wide consumption of pectin, the immune response to 10A is comparable to the responses to other serotypes. An antipectin antibody can opsonize serotype 10A pneumococci, and the shared βGal(1-6) may be useful as a simple vaccine against 10A. Impact of food glycans should be considered in host-pathogen interactions and future vaccine designs. IMPORTANCE The impact of food consumption on vaccine responses is unknown. Streptococcus pneumoniae (the pneumococcus) is an important human pathogen, and its polysaccharide capsule is used as a vaccine. We show that capsule type 10A in a pneumococcal vaccine shares an antigenic epitope, βGal(1-6), with pectin, which is in many plant foods and is widely consumed. Immune response to 10A is comparable to that seen with other capsule types, and pectin ingestion may have little impact on vaccine responses. However, antibody to pectin can kill serotype 10A pneumococci and this shared epitope may be considered in pneumococcal vaccine designs.Moon H. NahmJigui YuJiri VlachMaor Bar-PeledAmerican Society for MicrobiologyarticlefoodbacteriavaccinepolysaccharideStreptococcus pneumoniaecapsuleMicrobiologyQR1-502ENmSphere, Vol 5, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	food bacteria vaccine polysaccharide Streptococcus pneumoniae capsule Microbiology QR1-502
spellingShingle	food bacteria vaccine polysaccharide Streptococcus pneumoniae capsule Microbiology QR1-502 Moon H. Nahm Jigui Yu Jiri Vlach Maor Bar-Peled A Common Food Glycan, Pectin, Shares an Antigen with <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Capsule
description	ABSTRACT We are exposed daily to many glycans from bacteria and food plants. Bacterial glycans are generally antigenic and elicit antibody responses. It is unclear if food glycans’ sharing of antigens with bacterial glycans influences our immune responses to bacteria. We studied 14 different plant foods for cross-reactivity with monoclonal antibodies (MAbs) against 24 pneumococcal serotypes which commonly cause infections and are included in pneumococcal vaccines. Serotype 15B-specific MAb cross-reacts with fruit peels, and serotype 10A MAb cross-reacts with many natural and processed plant foods. The serotype 10A cross-reactive epitope is 1,6-β-galactosidase [βGal(1-6)], present in the rhamno-galacturonan I (RG-I) domain of pectin. Despite wide consumption of pectin, the immune response to 10A is comparable to the responses to other serotypes. An antipectin antibody can opsonize serotype 10A pneumococci, and the shared βGal(1-6) may be useful as a simple vaccine against 10A. Impact of food glycans should be considered in host-pathogen interactions and future vaccine designs. IMPORTANCE The impact of food consumption on vaccine responses is unknown. Streptococcus pneumoniae (the pneumococcus) is an important human pathogen, and its polysaccharide capsule is used as a vaccine. We show that capsule type 10A in a pneumococcal vaccine shares an antigenic epitope, βGal(1-6), with pectin, which is in many plant foods and is widely consumed. Immune response to 10A is comparable to that seen with other capsule types, and pectin ingestion may have little impact on vaccine responses. However, antibody to pectin can kill serotype 10A pneumococci and this shared epitope may be considered in pneumococcal vaccine designs.
format	article
author	Moon H. Nahm Jigui Yu Jiri Vlach Maor Bar-Peled
author_facet	Moon H. Nahm Jigui Yu Jiri Vlach Maor Bar-Peled
author_sort	Moon H. Nahm
title	A Common Food Glycan, Pectin, Shares an Antigen with <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Capsule
title_short	A Common Food Glycan, Pectin, Shares an Antigen with <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Capsule
title_full	A Common Food Glycan, Pectin, Shares an Antigen with <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Capsule
title_fullStr	A Common Food Glycan, Pectin, Shares an Antigen with <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Capsule
title_full_unstemmed	A Common Food Glycan, Pectin, Shares an Antigen with <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Capsule
title_sort	common food glycan, pectin, shares an antigen with <named-content content-type="genus-species">streptococcus pneumoniae</named-content> capsule
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/d64b9d1ae2864738a32cbe4a6d28c23d
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A Common Food Glycan, Pectin, Shares an Antigen with <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Capsule

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