Effect of pregnancy for females born small on later life metabolic disease risk.

There is a strong inverse relationship between a females own birth weight and her subsequent risk for gestational diabetes with increased risk of developing diabetes later in life. We have shown that growth restricted females develop loss of glucose tolerance during late pregnancy with normal pancre...

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Autores principales:	Melanie Tran, Linda A Gallo, Glenn D Wadley, Andrew J Jefferies, Karen M Moritz, Mary E Wlodek
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d64ceb41f27446fd91d917e50f3be801
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spelling	oai:doaj.org-article:d64ceb41f27446fd91d917e50f3be8012021-11-18T07:05:37ZEffect of pregnancy for females born small on later life metabolic disease risk.1932-620310.1371/journal.pone.0045188https://doaj.org/article/d64ceb41f27446fd91d917e50f3be8012012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028837/?tool=EBIhttps://doaj.org/toc/1932-6203There is a strong inverse relationship between a females own birth weight and her subsequent risk for gestational diabetes with increased risk of developing diabetes later in life. We have shown that growth restricted females develop loss of glucose tolerance during late pregnancy with normal pancreatic function. The aim of this study was to determine whether growth restricted females develop long-term impairment of metabolic control after an adverse pregnancy adaptation. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham surgery (Control) in late pregnancy (E18) in F0 female rats. F1 Control and Restricted female offspring were mated with normal males and allowed to deliver (termed Ex-Pregnant). Age-matched Control and Restricted Virgins were also studied and glucose tolerance and insulin secretion were determined. Pancreatic morphology and hepatic glycogen and triacylglycerol content were quantified respectively. Restricted females were born lighter than Control and remained lighter at all time points studied (p<0.05). Glucose tolerance, first phase insulin secretion and liver glycogen and triacylglycerol content were not different across groups, with no changes in β-cell mass. Second phase insulin secretion was reduced in Restricted Virgins (-34%, p<0.05) compared to Control Virgins, suggestive of enhanced peripheral insulin sensitivity but this was lost after pregnancy. Growth restriction was associated with enhanced basal hepatic insulin sensitivity, which may provide compensatory benefits to prevent adverse metabolic outcomes often associated with being born small. A prior pregnancy was associated with reduced hepatic insulin sensitivity with effects more pronounced in Controls than Restricted. Our data suggests that pregnancy ameliorates the enhanced peripheral insulin sensitivity in growth restricted females and has deleterious effects for hepatic insulin sensitivity, regardless of maternal birth weight.Melanie TranLinda A GalloGlenn D WadleyAndrew J JefferiesKaren M MoritzMary E WlodekPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45188 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Melanie Tran Linda A Gallo Glenn D Wadley Andrew J Jefferies Karen M Moritz Mary E Wlodek Effect of pregnancy for females born small on later life metabolic disease risk.
description	There is a strong inverse relationship between a females own birth weight and her subsequent risk for gestational diabetes with increased risk of developing diabetes later in life. We have shown that growth restricted females develop loss of glucose tolerance during late pregnancy with normal pancreatic function. The aim of this study was to determine whether growth restricted females develop long-term impairment of metabolic control after an adverse pregnancy adaptation. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham surgery (Control) in late pregnancy (E18) in F0 female rats. F1 Control and Restricted female offspring were mated with normal males and allowed to deliver (termed Ex-Pregnant). Age-matched Control and Restricted Virgins were also studied and glucose tolerance and insulin secretion were determined. Pancreatic morphology and hepatic glycogen and triacylglycerol content were quantified respectively. Restricted females were born lighter than Control and remained lighter at all time points studied (p<0.05). Glucose tolerance, first phase insulin secretion and liver glycogen and triacylglycerol content were not different across groups, with no changes in β-cell mass. Second phase insulin secretion was reduced in Restricted Virgins (-34%, p<0.05) compared to Control Virgins, suggestive of enhanced peripheral insulin sensitivity but this was lost after pregnancy. Growth restriction was associated with enhanced basal hepatic insulin sensitivity, which may provide compensatory benefits to prevent adverse metabolic outcomes often associated with being born small. A prior pregnancy was associated with reduced hepatic insulin sensitivity with effects more pronounced in Controls than Restricted. Our data suggests that pregnancy ameliorates the enhanced peripheral insulin sensitivity in growth restricted females and has deleterious effects for hepatic insulin sensitivity, regardless of maternal birth weight.
format	article
author	Melanie Tran Linda A Gallo Glenn D Wadley Andrew J Jefferies Karen M Moritz Mary E Wlodek
author_facet	Melanie Tran Linda A Gallo Glenn D Wadley Andrew J Jefferies Karen M Moritz Mary E Wlodek
author_sort	Melanie Tran
title	Effect of pregnancy for females born small on later life metabolic disease risk.
title_short	Effect of pregnancy for females born small on later life metabolic disease risk.
title_full	Effect of pregnancy for females born small on later life metabolic disease risk.
title_fullStr	Effect of pregnancy for females born small on later life metabolic disease risk.
title_full_unstemmed	Effect of pregnancy for females born small on later life metabolic disease risk.
title_sort	effect of pregnancy for females born small on later life metabolic disease risk.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d64ceb41f27446fd91d917e50f3be801
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Effect of pregnancy for females born small on later life metabolic disease risk.

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