Q223R polymorphism of the LEPR and obesity

The problem of overweight and obesity is one of the most urgent health issues in the world. 13 % of girls and 21 % of boys aged 11 suffer from overweight in the Russian Federation. The main causes of pubertal obesity are endocrine pathology, lifestyle and genetic disorders including mutation and pol...

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Autores principales:	K. D. Ievleva, L. V. Rychkova, E. A. Sheneman, T. A. Bairova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	adolescent females overweight obesity lepr q223r Science Q
Acceso en línea:	https://doaj.org/article/d655580d22a24f4382a6922437497335
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spelling	oai:doaj.org-article:d655580d22a24f4382a69224374973352021-11-23T06:14:36ZQ223R polymorphism of the LEPR and obesity2541-94202587-959610.12737/23419https://doaj.org/article/d655580d22a24f4382a69224374973352016-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/303https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The problem of overweight and obesity is one of the most urgent health issues in the world. 13 % of girls and 21 % of boys aged 11 suffer from overweight in the Russian Federation. The main causes of pubertal obesity are endocrine pathology, lifestyle and genetic disorders including mutation and polymorphisms of different metabolic pathways. Leptin produced in adipose tissue participates in reproduction regulation, glucose homeostasis, bone formation, etc. These effects are provided by leptin receptors coding LEPR gene. Q223R (rs1137101) polymorphism is associated with an increased serum level of leptin and overweight. There is no exact information about association between this polymorphism and obesity of adolescent females. The objective was to reveal LEPR Q223R polymorphism association between overweight and obesity in adolescent females. 123 Caucasian adolescent females were involved in this study. All samples could be separated into two groups: the girls with normal weight (SDS BM1 ± 1.0; control group), girls with overweight and obesity (SDS BM1 > +1.0-2.0; studied group). Anthropometric measurements (weight, height, waist and hip circumference, body fat percentage) were taken, and genotyping was performed using polymerase chain reaction with electrophoresis detection. G-allele frequency was 43.1 % in control and 40 % in the clinical group. We found no significant differences of the prevalence of polymorphism Q223R between the studied groups (р = 0,862). Furthermore, there was no association between the carriage of AG and GG with weight, BM1, body fat percentage, waist and hip circumference in both groups (р > 0.05). We have not found any association between LEPR Q223R and overweight and obesity in adolescent females.K. D. IevlevaL. V. RychkovaE. A. ShenemanT. A. BairovaScientific Сentre for Family Health and Human Reproduction Problemsarticleadolescent femalesoverweightobesitylepr q223rScienceQRUActa Biomedica Scientifica, Vol 1, Iss 5, Pp 170-174 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	adolescent females overweight obesity lepr q223r Science Q
spellingShingle	adolescent females overweight obesity lepr q223r Science Q K. D. Ievleva L. V. Rychkova E. A. Sheneman T. A. Bairova Q223R polymorphism of the LEPR and obesity
description	The problem of overweight and obesity is one of the most urgent health issues in the world. 13 % of girls and 21 % of boys aged 11 suffer from overweight in the Russian Federation. The main causes of pubertal obesity are endocrine pathology, lifestyle and genetic disorders including mutation and polymorphisms of different metabolic pathways. Leptin produced in adipose tissue participates in reproduction regulation, glucose homeostasis, bone formation, etc. These effects are provided by leptin receptors coding LEPR gene. Q223R (rs1137101) polymorphism is associated with an increased serum level of leptin and overweight. There is no exact information about association between this polymorphism and obesity of adolescent females. The objective was to reveal LEPR Q223R polymorphism association between overweight and obesity in adolescent females. 123 Caucasian adolescent females were involved in this study. All samples could be separated into two groups: the girls with normal weight (SDS BM1 ± 1.0; control group), girls with overweight and obesity (SDS BM1 > +1.0-2.0; studied group). Anthropometric measurements (weight, height, waist and hip circumference, body fat percentage) were taken, and genotyping was performed using polymerase chain reaction with electrophoresis detection. G-allele frequency was 43.1 % in control and 40 % in the clinical group. We found no significant differences of the prevalence of polymorphism Q223R between the studied groups (р = 0,862). Furthermore, there was no association between the carriage of AG and GG with weight, BM1, body fat percentage, waist and hip circumference in both groups (р > 0.05). We have not found any association between LEPR Q223R and overweight and obesity in adolescent females.
format	article
author	K. D. Ievleva L. V. Rychkova E. A. Sheneman T. A. Bairova
author_facet	K. D. Ievleva L. V. Rychkova E. A. Sheneman T. A. Bairova
author_sort	K. D. Ievleva
title	Q223R polymorphism of the LEPR and obesity
title_short	Q223R polymorphism of the LEPR and obesity
title_full	Q223R polymorphism of the LEPR and obesity
title_fullStr	Q223R polymorphism of the LEPR and obesity
title_full_unstemmed	Q223R polymorphism of the LEPR and obesity
title_sort	q223r polymorphism of the lepr and obesity
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/d655580d22a24f4382a6922437497335
work_keys_str_mv	AT kdievleva q223rpolymorphismoftheleprandobesity AT lvrychkova q223rpolymorphismoftheleprandobesity AT easheneman q223rpolymorphismoftheleprandobesity AT tabairova q223rpolymorphismoftheleprandobesity
_version_	1718417037030588416

Q223R polymorphism of the LEPR and obesity

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