Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia

Background. Autoimmune polyglandular syndrome type 1 (APS type 1) is a rare inherited autoimmune disease caused by mutations in AIRE gene (autoimmune regulator) and characterized by list of components. Diabetes mellitus (DM) can be one of components of this disease. Aims. To show frequency of DM in...

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Autores principales:	Leila S. Sozaeva, Lubov I. Zilberman, Galina N. Svetlova, Ekaterina A. Andrianova, Maria A. Kareva, Olga N. Ivanova, Svetlana M. Stepanova, Larisa V. Savelyeva, Alexandr Y. Mayorov, Ekaterina A. Troshina, Elizaveta M. Orlova, Eystein S. Husebye, Valentina A. Peterkova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2018
Materias:	autoimmune polyglandular syndrome type 1 aire diabetes mellitus antibodies glutamate decarboxylase tyrosine phosphatase zinc transporter-8 insulin β-cells of pancreas Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/d65b388c5d854351b4a44c51cabd9441
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spelling	oai:doaj.org-article:d65b388c5d854351b4a44c51cabd94412021-11-14T09:00:21ZClinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia2072-03512072-037810.14341/DM9347https://doaj.org/article/d65b388c5d854351b4a44c51cabd94412018-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/9347https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background. Autoimmune polyglandular syndrome type 1 (APS type 1) is a rare inherited autoimmune disease caused by mutations in AIRE gene (autoimmune regulator) and characterized by list of components. Diabetes mellitus (DM) can be one of components of this disease. Aims. To show frequency of DM in patients with APS type 1 in Russia, to describe clinical and immunological aspects of DM in patients with APS type 1 Materials and methods. 113 patients have been enrolled in the study, 16 of them had DM (15/16) or impaired glucose tolerance (1/16). Antibodies against glutamate decarboxylase, tyrosine phosphatase, zinc transporter-8, insulin and β-cells of pancreas were investigated in 30 patients with APS type 1 without DM and in 11 patients with APS type 1 and DM. ELISA test was used for detection autoantibodies. Results. Frequency of DM in patients with APS type 1 in Russia is 14.1% (16/113). Some patients had slow-progressive DM – 19%(3/16). Antibodies against insulin and β-cells were not specific and also were not sensitive markers for DM in APS type 1. Antibodies against tyrosine phosphatase and zinc transporter-8 test showed high specificity (100% и 97%), but low sensitivity (42% и 33,3%). Antibodies against glutamate decarboxylase were less specific (70%) and had very low sensitivity (58,3%). Conclusions. Frequency of DM in patients with APS type 1 in Russia is high to compare to other countries. 20% of Russian patients had slow-progressive course of DM. Antibodies against tyrosine phosphatase and zinc transporter-8 were the most specific for DM in patients with APS type 1, but sensitivity of these antibodies was low.Leila S. SozaevaLubov I. ZilbermanGalina N. SvetlovaEkaterina A. AndrianovaMaria A. KarevaOlga N. IvanovaSvetlana M. StepanovaLarisa V. SavelyevaAlexandr Y. MayorovEkaterina A. TroshinaElizaveta M. OrlovaEystein S. HusebyeValentina A. PeterkovaEndocrinology Research Centrearticleautoimmune polyglandular syndrome type 1airediabetes mellitusantibodiesglutamate decarboxylasetyrosine phosphatasezinc transporter-8insulinβ-cells of pancreasNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 21, Iss 1, Pp 48-57 (2018)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	autoimmune polyglandular syndrome type 1 aire diabetes mellitus antibodies glutamate decarboxylase tyrosine phosphatase zinc transporter-8 insulin β-cells of pancreas Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	autoimmune polyglandular syndrome type 1 aire diabetes mellitus antibodies glutamate decarboxylase tyrosine phosphatase zinc transporter-8 insulin β-cells of pancreas Nutritional diseases. Deficiency diseases RC620-627 Leila S. Sozaeva Lubov I. Zilberman Galina N. Svetlova Ekaterina A. Andrianova Maria A. Kareva Olga N. Ivanova Svetlana M. Stepanova Larisa V. Savelyeva Alexandr Y. Mayorov Ekaterina A. Troshina Elizaveta M. Orlova Eystein S. Husebye Valentina A. Peterkova Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia
description	Background. Autoimmune polyglandular syndrome type 1 (APS type 1) is a rare inherited autoimmune disease caused by mutations in AIRE gene (autoimmune regulator) and characterized by list of components. Diabetes mellitus (DM) can be one of components of this disease. Aims. To show frequency of DM in patients with APS type 1 in Russia, to describe clinical and immunological aspects of DM in patients with APS type 1 Materials and methods. 113 patients have been enrolled in the study, 16 of them had DM (15/16) or impaired glucose tolerance (1/16). Antibodies against glutamate decarboxylase, tyrosine phosphatase, zinc transporter-8, insulin and β-cells of pancreas were investigated in 30 patients with APS type 1 without DM and in 11 patients with APS type 1 and DM. ELISA test was used for detection autoantibodies. Results. Frequency of DM in patients with APS type 1 in Russia is 14.1% (16/113). Some patients had slow-progressive DM – 19%(3/16). Antibodies against insulin and β-cells were not specific and also were not sensitive markers for DM in APS type 1. Antibodies against tyrosine phosphatase and zinc transporter-8 test showed high specificity (100% и 97%), but low sensitivity (42% и 33,3%). Antibodies against glutamate decarboxylase were less specific (70%) and had very low sensitivity (58,3%). Conclusions. Frequency of DM in patients with APS type 1 in Russia is high to compare to other countries. 20% of Russian patients had slow-progressive course of DM. Antibodies against tyrosine phosphatase and zinc transporter-8 were the most specific for DM in patients with APS type 1, but sensitivity of these antibodies was low.
format	article
author	Leila S. Sozaeva Lubov I. Zilberman Galina N. Svetlova Ekaterina A. Andrianova Maria A. Kareva Olga N. Ivanova Svetlana M. Stepanova Larisa V. Savelyeva Alexandr Y. Mayorov Ekaterina A. Troshina Elizaveta M. Orlova Eystein S. Husebye Valentina A. Peterkova
author_facet	Leila S. Sozaeva Lubov I. Zilberman Galina N. Svetlova Ekaterina A. Andrianova Maria A. Kareva Olga N. Ivanova Svetlana M. Stepanova Larisa V. Savelyeva Alexandr Y. Mayorov Ekaterina A. Troshina Elizaveta M. Orlova Eystein S. Husebye Valentina A. Peterkova
author_sort	Leila S. Sozaeva
title	Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia
title_short	Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia
title_full	Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia
title_fullStr	Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia
title_full_unstemmed	Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia
title_sort	clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in russia
publisher	Endocrinology Research Centre
publishDate	2018
url	https://doaj.org/article/d65b388c5d854351b4a44c51cabd9441
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Clinical and immunological characteristics of diabetes mellitus in patients with autoimmune polyglandular syndrome type 1 in Russia

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