Distinct DNA repair pathways cause genomic instability at alternative DNA structures

Z-DNA-forming CG repeats are mutagenic in mammalian cells but the mechanism has remained unknown so far. Here, the authors show that the nucleotide excision repair complex Rad10-Rad1 (ERCC1-XPF) and the mismatch repair complex Msh2-Msh3 (MSH2-MSH3) are required for Z-DNA-induced genetic instability...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jennifer A. McKinney, Guliang Wang, Anirban Mukherjee, Laura Christensen, Sai H. Sankara Subramanian, Junhua Zhao, Karen M. Vasquez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d65c82d969c54965b636079be58de928
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d65c82d969c54965b636079be58de928
record_format	dspace
spelling	oai:doaj.org-article:d65c82d969c54965b636079be58de9282021-12-02T14:41:12ZDistinct DNA repair pathways cause genomic instability at alternative DNA structures10.1038/s41467-019-13878-92041-1723https://doaj.org/article/d65c82d969c54965b636079be58de9282020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13878-9https://doaj.org/toc/2041-1723Z-DNA-forming CG repeats are mutagenic in mammalian cells but the mechanism has remained unknown so far. Here, the authors show that the nucleotide excision repair complex Rad10-Rad1 (ERCC1-XPF) and the mismatch repair complex Msh2-Msh3 (MSH2-MSH3) are required for Z-DNA-induced genetic instability in yeast and human cells.Jennifer A. McKinneyGuliang WangAnirban MukherjeeLaura ChristensenSai H. Sankara SubramanianJunhua ZhaoKaren M. VasquezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer A. McKinney Guliang Wang Anirban Mukherjee Laura Christensen Sai H. Sankara Subramanian Junhua Zhao Karen M. Vasquez Distinct DNA repair pathways cause genomic instability at alternative DNA structures
description	Z-DNA-forming CG repeats are mutagenic in mammalian cells but the mechanism has remained unknown so far. Here, the authors show that the nucleotide excision repair complex Rad10-Rad1 (ERCC1-XPF) and the mismatch repair complex Msh2-Msh3 (MSH2-MSH3) are required for Z-DNA-induced genetic instability in yeast and human cells.
format	article
author	Jennifer A. McKinney Guliang Wang Anirban Mukherjee Laura Christensen Sai H. Sankara Subramanian Junhua Zhao Karen M. Vasquez
author_facet	Jennifer A. McKinney Guliang Wang Anirban Mukherjee Laura Christensen Sai H. Sankara Subramanian Junhua Zhao Karen M. Vasquez
author_sort	Jennifer A. McKinney
title	Distinct DNA repair pathways cause genomic instability at alternative DNA structures
title_short	Distinct DNA repair pathways cause genomic instability at alternative DNA structures
title_full	Distinct DNA repair pathways cause genomic instability at alternative DNA structures
title_fullStr	Distinct DNA repair pathways cause genomic instability at alternative DNA structures
title_full_unstemmed	Distinct DNA repair pathways cause genomic instability at alternative DNA structures
title_sort	distinct dna repair pathways cause genomic instability at alternative dna structures
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d65c82d969c54965b636079be58de928
work_keys_str_mv	AT jenniferamckinney distinctdnarepairpathwayscausegenomicinstabilityatalternativednastructures AT guliangwang distinctdnarepairpathwayscausegenomicinstabilityatalternativednastructures AT anirbanmukherjee distinctdnarepairpathwayscausegenomicinstabilityatalternativednastructures AT laurachristensen distinctdnarepairpathwayscausegenomicinstabilityatalternativednastructures AT saihsankarasubramanian distinctdnarepairpathwayscausegenomicinstabilityatalternativednastructures AT junhuazhao distinctdnarepairpathwayscausegenomicinstabilityatalternativednastructures AT karenmvasquez distinctdnarepairpathwayscausegenomicinstabilityatalternativednastructures
_version_	1718390023673348096

Distinct DNA repair pathways cause genomic instability at alternative DNA structures

Ejemplares similares