Treatment of invasive candidiasis in the elderly: a review

Aikaterini Flevari,1 Maria Theodorakopoulou,1 Aristea Velegraki,2 Apostolos Armaganidis,1 George Dimopoulos1 1Department of Critical Care, University Hospital Attikon, Medical School, 2Mycology Laboratory, Department of Microbiology, Medical School, University of Athens, Athens, Greece Abstract: Fu...

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Autores principales:	Flevari A, Theodorakopoulou M, Velegraki A, Armaganidis A, Dimopoulos G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	emerging fungal infections elderly patients treatment Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d65d12d858984340a0c0a93f3add5146
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spelling	oai:doaj.org-article:d65d12d858984340a0c0a93f3add51462021-12-02T00:22:04ZTreatment of invasive candidiasis in the elderly: a review1178-1998https://doaj.org/article/d65d12d858984340a0c0a93f3add51462013-09-01T00:00:00Zhttps://www.dovepress.com/treatment-of-invasive-candidiasis-in-the-elderly-a-review-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Aikaterini Flevari,1 Maria Theodorakopoulou,1 Aristea Velegraki,2 Apostolos Armaganidis,1 George Dimopoulos1 1Department of Critical Care, University Hospital Attikon, Medical School, 2Mycology Laboratory, Department of Microbiology, Medical School, University of Athens, Athens, Greece Abstract: Fungi are major causes of infections among immunocompromised or hospitalized patients with serious underlying diseases and comorbidities. Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections. The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species. Comorbidities and multidrug use should be taken into account any time the therapeutic regimen is under consideration. Different classes of antifungal drugs are available for the treatment of invasive fungal infections but echinocandins, apart from their activity against resistant strains (Candida glabrata and Candida krusei), seem to be safe, with limited adverse events and minimal drug–drug interactions in comparison to the other regimens. Therefore, these agents are strongly recommended when dealing with elderly patients suffering from an invasive form of Candida infection. Keywords: emerging fungal infections, elderly patients, treatmentFlevari ATheodorakopoulou MVelegraki AArmaganidis ADimopoulos GDove Medical Pressarticleemerging fungal infectionselderly patientstreatmentGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 1199-1208 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	emerging fungal infections elderly patients treatment Geriatrics RC952-954.6
spellingShingle	emerging fungal infections elderly patients treatment Geriatrics RC952-954.6 Flevari A Theodorakopoulou M Velegraki A Armaganidis A Dimopoulos G Treatment of invasive candidiasis in the elderly: a review
description	Aikaterini Flevari,1 Maria Theodorakopoulou,1 Aristea Velegraki,2 Apostolos Armaganidis,1 George Dimopoulos1 1Department of Critical Care, University Hospital Attikon, Medical School, 2Mycology Laboratory, Department of Microbiology, Medical School, University of Athens, Athens, Greece Abstract: Fungi are major causes of infections among immunocompromised or hospitalized patients with serious underlying diseases and comorbidities. Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections. The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species. Comorbidities and multidrug use should be taken into account any time the therapeutic regimen is under consideration. Different classes of antifungal drugs are available for the treatment of invasive fungal infections but echinocandins, apart from their activity against resistant strains (Candida glabrata and Candida krusei), seem to be safe, with limited adverse events and minimal drug–drug interactions in comparison to the other regimens. Therefore, these agents are strongly recommended when dealing with elderly patients suffering from an invasive form of Candida infection. Keywords: emerging fungal infections, elderly patients, treatment
format	article
author	Flevari A Theodorakopoulou M Velegraki A Armaganidis A Dimopoulos G
author_facet	Flevari A Theodorakopoulou M Velegraki A Armaganidis A Dimopoulos G
author_sort	Flevari A
title	Treatment of invasive candidiasis in the elderly: a review
title_short	Treatment of invasive candidiasis in the elderly: a review
title_full	Treatment of invasive candidiasis in the elderly: a review
title_fullStr	Treatment of invasive candidiasis in the elderly: a review
title_full_unstemmed	Treatment of invasive candidiasis in the elderly: a review
title_sort	treatment of invasive candidiasis in the elderly: a review
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d65d12d858984340a0c0a93f3add5146
work_keys_str_mv	AT flevaria treatmentofinvasivecandidiasisintheelderlyareview AT theodorakopouloum treatmentofinvasivecandidiasisintheelderlyareview AT velegrakia treatmentofinvasivecandidiasisintheelderlyareview AT armaganidisa treatmentofinvasivecandidiasisintheelderlyareview AT dimopoulosg treatmentofinvasivecandidiasisintheelderlyareview
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Treatment of invasive candidiasis in the elderly: a review

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