Resting state brain networks in the prairie vole

Abstract Resting state functional magnetic resonance imaging (rsfMRI) has shown the hierarchical organization of the human brain into large-scale complex networks, referred as resting state networks. This technique has turned into a promising translational research tool after the finding of similar...

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Autores principales:	Juan J. Ortiz, Wendy Portillo, Raul G. Paredes, Larry J. Young, Sarael Alcauter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d65e2e5bca474cf18e5ace70343d2f66
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spelling	oai:doaj.org-article:d65e2e5bca474cf18e5ace70343d2f662021-12-02T15:05:02ZResting state brain networks in the prairie vole10.1038/s41598-017-17610-92045-2322https://doaj.org/article/d65e2e5bca474cf18e5ace70343d2f662018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-17610-9https://doaj.org/toc/2045-2322Abstract Resting state functional magnetic resonance imaging (rsfMRI) has shown the hierarchical organization of the human brain into large-scale complex networks, referred as resting state networks. This technique has turned into a promising translational research tool after the finding of similar resting state networks in non-human primates, rodents and other animal models of great value for neuroscience. Here, we demonstrate and characterize the presence of resting states networks in Microtus ochrogaster, the prairie vole, an extraordinary animal model to study complex human-like social behavior, with potential implications for the research of normal social development, addiction and neuropsychiatric disorders. Independent component analysis of rsfMRI data from isoflurane-anestethized prairie voles resulted in cortical and subcortical networks, including primary motor and sensory networks, but also included putative salience and default mode networks. We further discuss how future research could help to close the gap between the properties of the large scale functional organization and the underlying neurobiology of several aspects of social cognition. These results contribute to the evidence of preserved resting state brain networks across species and provide the foundations to explore the use of rsfMRI in the prairie vole for basic and translational research.Juan J. OrtizWendy PortilloRaul G. ParedesLarry J. YoungSarael AlcauterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan J. Ortiz Wendy Portillo Raul G. Paredes Larry J. Young Sarael Alcauter Resting state brain networks in the prairie vole
description	Abstract Resting state functional magnetic resonance imaging (rsfMRI) has shown the hierarchical organization of the human brain into large-scale complex networks, referred as resting state networks. This technique has turned into a promising translational research tool after the finding of similar resting state networks in non-human primates, rodents and other animal models of great value for neuroscience. Here, we demonstrate and characterize the presence of resting states networks in Microtus ochrogaster, the prairie vole, an extraordinary animal model to study complex human-like social behavior, with potential implications for the research of normal social development, addiction and neuropsychiatric disorders. Independent component analysis of rsfMRI data from isoflurane-anestethized prairie voles resulted in cortical and subcortical networks, including primary motor and sensory networks, but also included putative salience and default mode networks. We further discuss how future research could help to close the gap between the properties of the large scale functional organization and the underlying neurobiology of several aspects of social cognition. These results contribute to the evidence of preserved resting state brain networks across species and provide the foundations to explore the use of rsfMRI in the prairie vole for basic and translational research.
format	article
author	Juan J. Ortiz Wendy Portillo Raul G. Paredes Larry J. Young Sarael Alcauter
author_facet	Juan J. Ortiz Wendy Portillo Raul G. Paredes Larry J. Young Sarael Alcauter
author_sort	Juan J. Ortiz
title	Resting state brain networks in the prairie vole
title_short	Resting state brain networks in the prairie vole
title_full	Resting state brain networks in the prairie vole
title_fullStr	Resting state brain networks in the prairie vole
title_full_unstemmed	Resting state brain networks in the prairie vole
title_sort	resting state brain networks in the prairie vole
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d65e2e5bca474cf18e5ace70343d2f66
work_keys_str_mv	AT juanjortiz restingstatebrainnetworksintheprairievole AT wendyportillo restingstatebrainnetworksintheprairievole AT raulgparedes restingstatebrainnetworksintheprairievole AT larryjyoung restingstatebrainnetworksintheprairievole AT saraelalcauter restingstatebrainnetworksintheprairievole
_version_	1718388985631342592

Resting state brain networks in the prairie vole

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