Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and monocytes in the specific induction of Th1, Th2 or Th...
Saved in:
Main Authors: | Kerry L. Hilligan, Shiau-Choot Tang, Evelyn J. Hyde, Elsa Roussel, Johannes U. Mayer, Jianping Yang, Kirsty A. Wakelin, Alfonso J. Schmidt, Lisa M. Connor, Alan Sher, Andrew S. MacDonald, Franca Ronchese |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
|
Subjects: | |
Online Access: | https://doaj.org/article/d65f3d80f398424cae180d6d1bb01a61 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Murine melanoma-infiltrating dendritic cells are defective in antigen presenting function regardless of the presence of CD4CD25 regulatory T cells.
by: Haley Ataera, et al.
Published: (2011) -
Genomic programming of IRF4-expressing human Langerhans cells
by: Sofia Sirvent, et al.
Published: (2020) -
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
by: Aakanksha Jain, et al.
Published: (2018) -
The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival
by: Hiroto Ohguchi, et al.
Published: (2016) -
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
by: Lucia Campos Carrascosa, et al.
Published: (2017)