Structural and functional characterization of the bacterial biofilm activator RemA

Biofilm formation in Bacillus subtilis requires expression of matrix production genes, which are upregulated by transcriptional activator RemA. Here, the authors show that RemA forms octameric rings with the potential to form a 16-meric superstructure, suggesting that the protein can wrap DNA throug...

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Autores principales:	Tamara Hoffmann, Devid Mrusek, Patricia Bedrunka, Fabiana Burchert, Christopher-Nils Mais, Daniel B. Kearns, Florian Altegoer, Erhard Bremer, Gert Bange
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d65f8dc8c4264fadb72b501cc705fb6e
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spelling	oai:doaj.org-article:d65f8dc8c4264fadb72b501cc705fb6e2021-12-02T17:37:30ZStructural and functional characterization of the bacterial biofilm activator RemA10.1038/s41467-021-26005-42041-1723https://doaj.org/article/d65f8dc8c4264fadb72b501cc705fb6e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26005-4https://doaj.org/toc/2041-1723Biofilm formation in Bacillus subtilis requires expression of matrix production genes, which are upregulated by transcriptional activator RemA. Here, the authors show that RemA forms octameric rings with the potential to form a 16-meric superstructure, suggesting that the protein can wrap DNA through a LytTR-related domain.Tamara HoffmannDevid MrusekPatricia BedrunkaFabiana BurchertChristopher-Nils MaisDaniel B. KearnsFlorian AltegoerErhard BremerGert BangeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamara Hoffmann Devid Mrusek Patricia Bedrunka Fabiana Burchert Christopher-Nils Mais Daniel B. Kearns Florian Altegoer Erhard Bremer Gert Bange Structural and functional characterization of the bacterial biofilm activator RemA
description	Biofilm formation in Bacillus subtilis requires expression of matrix production genes, which are upregulated by transcriptional activator RemA. Here, the authors show that RemA forms octameric rings with the potential to form a 16-meric superstructure, suggesting that the protein can wrap DNA through a LytTR-related domain.
format	article
author	Tamara Hoffmann Devid Mrusek Patricia Bedrunka Fabiana Burchert Christopher-Nils Mais Daniel B. Kearns Florian Altegoer Erhard Bremer Gert Bange
author_facet	Tamara Hoffmann Devid Mrusek Patricia Bedrunka Fabiana Burchert Christopher-Nils Mais Daniel B. Kearns Florian Altegoer Erhard Bremer Gert Bange
author_sort	Tamara Hoffmann
title	Structural and functional characterization of the bacterial biofilm activator RemA
title_short	Structural and functional characterization of the bacterial biofilm activator RemA
title_full	Structural and functional characterization of the bacterial biofilm activator RemA
title_fullStr	Structural and functional characterization of the bacterial biofilm activator RemA
title_full_unstemmed	Structural and functional characterization of the bacterial biofilm activator RemA
title_sort	structural and functional characterization of the bacterial biofilm activator rema
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d65f8dc8c4264fadb72b501cc705fb6e
work_keys_str_mv	AT tamarahoffmann structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema AT devidmrusek structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema AT patriciabedrunka structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema AT fabianaburchert structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema AT christophernilsmais structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema AT danielbkearns structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema AT florianaltegoer structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema AT erhardbremer structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema AT gertbange structuralandfunctionalcharacterizationofthebacterialbiofilmactivatorrema
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Structural and functional characterization of the bacterial biofilm activator RemA

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