Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid

Abstract Childhood radiation exposure is a known thyroid cancer risk factor. This study evaluated the effects of age on radiation-induced thyroid carcinogenesis in rats irradiated with 8 Gy X-rays. We analyzed cell proliferation, cell death, DNA damage response, and autophagy-related markers in 4-we...

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Main Authors:	Mutsumi Matsuu-Matsuyama, Kazuko Shichijo, Katsuya Matsuda, Nariaki Fujimoto, Hisayoshi Kondo, Shiro Miura, Tomomi Kurashige, Yuji Nagayama, Masahiro Nakashima
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/d666540cb0a144dea163b11c33a132ac
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spelling	oai:doaj.org-article:d666540cb0a144dea163b11c33a132ac2021-12-02T19:16:59ZAge-dependent effects on radiation-induced carcinogenesis in the rat thyroid10.1038/s41598-021-98481-z2045-2322https://doaj.org/article/d666540cb0a144dea163b11c33a132ac2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98481-zhttps://doaj.org/toc/2045-2322Abstract Childhood radiation exposure is a known thyroid cancer risk factor. This study evaluated the effects of age on radiation-induced thyroid carcinogenesis in rats irradiated with 8 Gy X-rays. We analyzed cell proliferation, cell death, DNA damage response, and autophagy-related markers in 4-week-old (4W) and 7-month-old (7M) rats and the incidence of thyroid tumors in 4W, 4-month-old (4M), and 7M rats 18 months after irradiation. Cell death and DNA damage response were increased in 4W rats compared to those in controls at 1 month post-irradiation. More Ki-67-positive cells were observed in 4W rats at 12 months post-irradiation. Thyroid tumors were confirmed in 61.9% (13/21), 63.6% (7/11), and 33.3% (2/6) of irradiated 4W, 4M, and 7M rats, respectively, compared to 0%, 14.3% (1/7), and 16.7% (1/6) in the respective nonirradiated controls. There were 29, 9, and 2 tumors in irradiated 4W, 4M, and 7M rats, respectively. The expression of several autophagy components was downregulated in the area surrounding radiation-induced thyroid carcinomas in 4W and 7M rats. LC3 and p62 expression levels decreased in radiation-induced follicular carcinoma in 4W rats. Radiosensitive cells causing thyroid tumors may be more prevalent in young rats, and abrogation of autophagy may be associated with radiation-induced thyroid carcinogenesis.Mutsumi Matsuu-MatsuyamaKazuko ShichijoKatsuya MatsudaNariaki FujimotoHisayoshi KondoShiro MiuraTomomi KurashigeYuji NagayamaMasahiro NakashimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mutsumi Matsuu-Matsuyama Kazuko Shichijo Katsuya Matsuda Nariaki Fujimoto Hisayoshi Kondo Shiro Miura Tomomi Kurashige Yuji Nagayama Masahiro Nakashima Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid
description	Abstract Childhood radiation exposure is a known thyroid cancer risk factor. This study evaluated the effects of age on radiation-induced thyroid carcinogenesis in rats irradiated with 8 Gy X-rays. We analyzed cell proliferation, cell death, DNA damage response, and autophagy-related markers in 4-week-old (4W) and 7-month-old (7M) rats and the incidence of thyroid tumors in 4W, 4-month-old (4M), and 7M rats 18 months after irradiation. Cell death and DNA damage response were increased in 4W rats compared to those in controls at 1 month post-irradiation. More Ki-67-positive cells were observed in 4W rats at 12 months post-irradiation. Thyroid tumors were confirmed in 61.9% (13/21), 63.6% (7/11), and 33.3% (2/6) of irradiated 4W, 4M, and 7M rats, respectively, compared to 0%, 14.3% (1/7), and 16.7% (1/6) in the respective nonirradiated controls. There were 29, 9, and 2 tumors in irradiated 4W, 4M, and 7M rats, respectively. The expression of several autophagy components was downregulated in the area surrounding radiation-induced thyroid carcinomas in 4W and 7M rats. LC3 and p62 expression levels decreased in radiation-induced follicular carcinoma in 4W rats. Radiosensitive cells causing thyroid tumors may be more prevalent in young rats, and abrogation of autophagy may be associated with radiation-induced thyroid carcinogenesis.
format	article
author	Mutsumi Matsuu-Matsuyama Kazuko Shichijo Katsuya Matsuda Nariaki Fujimoto Hisayoshi Kondo Shiro Miura Tomomi Kurashige Yuji Nagayama Masahiro Nakashima
author_facet	Mutsumi Matsuu-Matsuyama Kazuko Shichijo Katsuya Matsuda Nariaki Fujimoto Hisayoshi Kondo Shiro Miura Tomomi Kurashige Yuji Nagayama Masahiro Nakashima
author_sort	Mutsumi Matsuu-Matsuyama
title	Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid
title_short	Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid
title_full	Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid
title_fullStr	Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid
title_full_unstemmed	Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid
title_sort	age-dependent effects on radiation-induced carcinogenesis in the rat thyroid
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d666540cb0a144dea163b11c33a132ac
work_keys_str_mv	AT mutsumimatsuumatsuyama agedependenteffectsonradiationinducedcarcinogenesisintheratthyroid AT kazukoshichijo agedependenteffectsonradiationinducedcarcinogenesisintheratthyroid AT katsuyamatsuda agedependenteffectsonradiationinducedcarcinogenesisintheratthyroid AT nariakifujimoto agedependenteffectsonradiationinducedcarcinogenesisintheratthyroid AT hisayoshikondo agedependenteffectsonradiationinducedcarcinogenesisintheratthyroid AT shiromiura agedependenteffectsonradiationinducedcarcinogenesisintheratthyroid AT tomomikurashige agedependenteffectsonradiationinducedcarcinogenesisintheratthyroid AT yujinagayama agedependenteffectsonradiationinducedcarcinogenesisintheratthyroid AT masahironakashima agedependenteffectsonradiationinducedcarcinogenesisintheratthyroid
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Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid

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