Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons.

Parkinson's disease (PD) is the second most common neurodegenerative disease. A key pathological feature of PD is Lewy bodies, of which the major protein component is α-synuclein (α-syn). Human genetic studies have shown that mutations (A53T, A30P, E46K) and multiplication of the α-syn gene are...

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Autores principales: Li Li, Sashi Nadanaciva, Zdenek Berger, Wei Shen, Katrina Paumier, Joel Schwartz, Kewa Mou, Paula Loos, Anthony J Milici, John Dunlop, Warren D Hirst
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/d66a11a109554bf685a5e666188f4884
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