Porcine FcγRIIb mediates enhancement of porcine reproductive and respiratory syndrome virus (PRRSV) infection.

Antibody-dependent enhancement (ADE) of virus infection caused by the uptake of virus-antibody complexes by FcγRs is a significant obstacle to the development of effective vaccines to control certain human and animal viral diseases. The activation FcγRs, including FcγRI and FcγRIIa have been shown t...

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Autores principales:	Songlin Qiao, Zhizheng Jiang, Xiaohui Tian, Rui Wang, Guangxu Xing, Bo Wan, Dengke Bao, Yonghui Liu, Huifang Hao, Junqing Guo, Gaiping Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d66a2c02ac004dd2b4d742cf56edd62c
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spelling	oai:doaj.org-article:d66a2c02ac004dd2b4d742cf56edd62c2021-11-18T07:31:18ZPorcine FcγRIIb mediates enhancement of porcine reproductive and respiratory syndrome virus (PRRSV) infection.1932-620310.1371/journal.pone.0028721https://doaj.org/article/d66a2c02ac004dd2b4d742cf56edd62c2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22220194/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Antibody-dependent enhancement (ADE) of virus infection caused by the uptake of virus-antibody complexes by FcγRs is a significant obstacle to the development of effective vaccines to control certain human and animal viral diseases. The activation FcγRs, including FcγRI and FcγRIIa have been shown to mediate ADE infection of virus. In the present paper, we showed that pocine FcγRIIb, an inhibitory FcγR, mediates ADE of PRRSV infection. Stable Marc-145 cell lines expressing poFcγRIIb (Marc-poFcγRII) were established. The relative yield of progeny virus was significantly increased in the presence of sub-neutralization anti-PRRSV antibody. The Fab fragment and normal porcine sera had no effect. Anti-poFcγRII antibody inhibited the enhancement of infection when cells were infected in the presence of anti-PRRSV antibody, but not when cells were infected in the absence of antibody. These results indicate that enhancement of infection in these cells by anti-PRRSV virus antibody is FcγRII-mediated. Identification of the inhibitory FcγR mediating ADE infection should expand our understanding of the mechanisms of pathogenesis for a broad range of infectious diseases and may open many approaches for improvements to the treatment and prevention of such diseases.Songlin QiaoZhizheng JiangXiaohui TianRui WangGuangxu XingBo WanDengke BaoYonghui LiuHuifang HaoJunqing GuoGaiping ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e28721 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Songlin Qiao Zhizheng Jiang Xiaohui Tian Rui Wang Guangxu Xing Bo Wan Dengke Bao Yonghui Liu Huifang Hao Junqing Guo Gaiping Zhang Porcine FcγRIIb mediates enhancement of porcine reproductive and respiratory syndrome virus (PRRSV) infection.
description	Antibody-dependent enhancement (ADE) of virus infection caused by the uptake of virus-antibody complexes by FcγRs is a significant obstacle to the development of effective vaccines to control certain human and animal viral diseases. The activation FcγRs, including FcγRI and FcγRIIa have been shown to mediate ADE infection of virus. In the present paper, we showed that pocine FcγRIIb, an inhibitory FcγR, mediates ADE of PRRSV infection. Stable Marc-145 cell lines expressing poFcγRIIb (Marc-poFcγRII) were established. The relative yield of progeny virus was significantly increased in the presence of sub-neutralization anti-PRRSV antibody. The Fab fragment and normal porcine sera had no effect. Anti-poFcγRII antibody inhibited the enhancement of infection when cells were infected in the presence of anti-PRRSV antibody, but not when cells were infected in the absence of antibody. These results indicate that enhancement of infection in these cells by anti-PRRSV virus antibody is FcγRII-mediated. Identification of the inhibitory FcγR mediating ADE infection should expand our understanding of the mechanisms of pathogenesis for a broad range of infectious diseases and may open many approaches for improvements to the treatment and prevention of such diseases.
format	article
author	Songlin Qiao Zhizheng Jiang Xiaohui Tian Rui Wang Guangxu Xing Bo Wan Dengke Bao Yonghui Liu Huifang Hao Junqing Guo Gaiping Zhang
author_facet	Songlin Qiao Zhizheng Jiang Xiaohui Tian Rui Wang Guangxu Xing Bo Wan Dengke Bao Yonghui Liu Huifang Hao Junqing Guo Gaiping Zhang
author_sort	Songlin Qiao
title	Porcine FcγRIIb mediates enhancement of porcine reproductive and respiratory syndrome virus (PRRSV) infection.
title_short	Porcine FcγRIIb mediates enhancement of porcine reproductive and respiratory syndrome virus (PRRSV) infection.
title_full	Porcine FcγRIIb mediates enhancement of porcine reproductive and respiratory syndrome virus (PRRSV) infection.
title_fullStr	Porcine FcγRIIb mediates enhancement of porcine reproductive and respiratory syndrome virus (PRRSV) infection.
title_full_unstemmed	Porcine FcγRIIb mediates enhancement of porcine reproductive and respiratory syndrome virus (PRRSV) infection.
title_sort	porcine fcγriib mediates enhancement of porcine reproductive and respiratory syndrome virus (prrsv) infection.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/d66a2c02ac004dd2b4d742cf56edd62c
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Porcine FcγRIIb mediates enhancement of porcine reproductive and respiratory syndrome virus (PRRSV) infection.

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