Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.

Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is characterized by the progressive and selective loss of upper and lower motor neurons. Diagnosis of this disorder is based on clinical assessment, and the average survival time is less than 3 years. Injections...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Caroline May, Eckhard Nordhoff, Swaantje Casjens, Michael Turewicz, Martin Eisenacher, Ralf Gold, Thomas Brüning, Beate Pesch, Christian Stephan, Dirk Woitalla, Botond Penke, Tamás Janáky, Dezső Virók, László Siklós, Jozsef I Engelhardt, Helmut E Meyer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d66aa02092b940ca9e65157f80c0ce06
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d66aa02092b940ca9e65157f80c0ce06
record_format	dspace
spelling	oai:doaj.org-article:d66aa02092b940ca9e65157f80c0ce062021-11-18T08:30:54ZHighly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.1932-620310.1371/journal.pone.0089596https://doaj.org/article/d66aa02092b940ca9e65157f80c0ce062014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586901/?tool=EBIhttps://doaj.org/toc/1932-6203Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is characterized by the progressive and selective loss of upper and lower motor neurons. Diagnosis of this disorder is based on clinical assessment, and the average survival time is less than 3 years. Injections of IgG from ALS patients into mice are known to specifically mark motor neurons. Moreover, IgG has been found in upper and lower motor neurons in ALS patients. These results led us to perform a case-control study using human protein microarrays to identify the antibody profiles of serum samples from 20 ALS patients and 20 healthy controls. We demonstrated high levels of 20 IgG antibodies that distinguished the patients from the controls. These findings suggest that a panel of antibodies may serve as a potential diagnostic biomarker for ALS.Caroline MayEckhard NordhoffSwaantje CasjensMichael TurewiczMartin EisenacherRalf GoldThomas BrüningBeate PeschChristian StephanDirk WoitallaBotond PenkeTamás JanákyDezső VirókLászló SiklósJozsef I EngelhardtHelmut E MeyerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89596 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caroline May Eckhard Nordhoff Swaantje Casjens Michael Turewicz Martin Eisenacher Ralf Gold Thomas Brüning Beate Pesch Christian Stephan Dirk Woitalla Botond Penke Tamás Janáky Dezső Virók László Siklós Jozsef I Engelhardt Helmut E Meyer Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.
description	Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is characterized by the progressive and selective loss of upper and lower motor neurons. Diagnosis of this disorder is based on clinical assessment, and the average survival time is less than 3 years. Injections of IgG from ALS patients into mice are known to specifically mark motor neurons. Moreover, IgG has been found in upper and lower motor neurons in ALS patients. These results led us to perform a case-control study using human protein microarrays to identify the antibody profiles of serum samples from 20 ALS patients and 20 healthy controls. We demonstrated high levels of 20 IgG antibodies that distinguished the patients from the controls. These findings suggest that a panel of antibodies may serve as a potential diagnostic biomarker for ALS.
format	article
author	Caroline May Eckhard Nordhoff Swaantje Casjens Michael Turewicz Martin Eisenacher Ralf Gold Thomas Brüning Beate Pesch Christian Stephan Dirk Woitalla Botond Penke Tamás Janáky Dezső Virók László Siklós Jozsef I Engelhardt Helmut E Meyer
author_facet	Caroline May Eckhard Nordhoff Swaantje Casjens Michael Turewicz Martin Eisenacher Ralf Gold Thomas Brüning Beate Pesch Christian Stephan Dirk Woitalla Botond Penke Tamás Janáky Dezső Virók László Siklós Jozsef I Engelhardt Helmut E Meyer
author_sort	Caroline May
title	Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.
title_short	Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.
title_full	Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.
title_fullStr	Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.
title_full_unstemmed	Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.
title_sort	highly immunoreactive igg antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d66aa02092b940ca9e65157f80c0ce06
work_keys_str_mv	AT carolinemay highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT eckhardnordhoff highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT swaantjecasjens highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT michaelturewicz highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT martineisenacher highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT ralfgold highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT thomasbruning highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT beatepesch highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT christianstephan highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT dirkwoitalla highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT botondpenke highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT tamasjanaky highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT dezsovirok highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT laszlosiklos highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT jozsefiengelhardt highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray AT helmutemeyer highlyimmunoreactiveiggantibodiesdirectedagainstasetoftwentyhumanproteinsintheseraofpatientswithamyotrophiclateralsclerosisidentifiedbyproteinarray
_version_	1718421711244754944

Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array.

Ejemplares similares