A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their subsequent maturation, and that inhibition of this pa...

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Autores principales:	Jung-Min Kim, Yeon-Suk Yang, Kwang Hwan Park, Xianpeng Ge, Ren Xu, Na Li, Minkyung Song, Hyunho Chun, Seoyeon Bok, Julia F. Charles, Odile Filhol-Cochet, Brigitte Boldyreff, Teresa Dinter, Paul B. Yu, Ning Kon, Wei Gu, Takeshi Takarada, Matthew B. Greenblatt, Jae-Hyuck Shim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d66c7cf3ddb9472bb8083540eab23003
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spelling	oai:doaj.org-article:d66c7cf3ddb9472bb8083540eab230032021-12-02T15:37:13ZA RUNX2 stabilization pathway mediates physiologic and pathologic bone formation10.1038/s41467-020-16038-62041-1723https://doaj.org/article/d66c7cf3ddb9472bb8083540eab230032020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16038-6https://doaj.org/toc/2041-1723Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their subsequent maturation, and that inhibition of this pathway can block heterotopic ossification.Jung-Min KimYeon-Suk YangKwang Hwan ParkXianpeng GeRen XuNa LiMinkyung SongHyunho ChunSeoyeon BokJulia F. CharlesOdile Filhol-CochetBrigitte BoldyreffTeresa DinterPaul B. YuNing KonWei GuTakeshi TakaradaMatthew B. GreenblattJae-Hyuck ShimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-Min Kim Yeon-Suk Yang Kwang Hwan Park Xianpeng Ge Ren Xu Na Li Minkyung Song Hyunho Chun Seoyeon Bok Julia F. Charles Odile Filhol-Cochet Brigitte Boldyreff Teresa Dinter Paul B. Yu Ning Kon Wei Gu Takeshi Takarada Matthew B. Greenblatt Jae-Hyuck Shim A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
description	Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their subsequent maturation, and that inhibition of this pathway can block heterotopic ossification.
format	article
author	Jung-Min Kim Yeon-Suk Yang Kwang Hwan Park Xianpeng Ge Ren Xu Na Li Minkyung Song Hyunho Chun Seoyeon Bok Julia F. Charles Odile Filhol-Cochet Brigitte Boldyreff Teresa Dinter Paul B. Yu Ning Kon Wei Gu Takeshi Takarada Matthew B. Greenblatt Jae-Hyuck Shim
author_facet	Jung-Min Kim Yeon-Suk Yang Kwang Hwan Park Xianpeng Ge Ren Xu Na Li Minkyung Song Hyunho Chun Seoyeon Bok Julia F. Charles Odile Filhol-Cochet Brigitte Boldyreff Teresa Dinter Paul B. Yu Ning Kon Wei Gu Takeshi Takarada Matthew B. Greenblatt Jae-Hyuck Shim
author_sort	Jung-Min Kim
title	A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
title_short	A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
title_full	A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
title_fullStr	A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
title_full_unstemmed	A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
title_sort	runx2 stabilization pathway mediates physiologic and pathologic bone formation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d66c7cf3ddb9472bb8083540eab23003
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A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

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