Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D3-Induced Hypercalcemia

The purpose of this study was to elucidate the effects of static electric field (SEF) treatment on vitamin D3 (Vit D3)-induced hypercalcemia and renal calcification in mice. The mice were assigned to three groups: Vit D3-treated mi...

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Autores principales:	Tohru Kimura, Kengo Inaka, Noboru Ogiso
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	calcification cardiac muscles complementary and integrative medicine electrolytes gastric mucosa histopathology Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d674c753e9cd4c86a387d4f36d4f34a2
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spelling	oai:doaj.org-article:d674c753e9cd4c86a387d4f36d4f34a22021-11-25T16:47:08ZDemonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D<sub>3</sub>-Induced Hypercalcemia10.3390/biology101111162079-7737https://doaj.org/article/d674c753e9cd4c86a387d4f36d4f34a22021-10-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1116https://doaj.org/toc/2079-7737The purpose of this study was to elucidate the effects of static electric field (SEF) treatment on vitamin D<sub>3</sub> (Vit D<sub>3</sub>)-induced hypercalcemia and renal calcification in mice. The mice were assigned to three groups: Vit D<sub>3</sub>-treated mice, mice treated with Vit D<sub>3</sub> and SEF (Vit D<sub>3</sub> + SEF), and untreated mice. After the administration of Vit D<sub>3</sub>, the Vit D<sub>3</sub> + SEF-treated mice were exposed to SEF treatment by a high-voltage alternating current over five days. Serum biochemical examinations revealed that both the creatinine and blood urea nitrogen concentrations were significantly higher in the Vit D<sub>3</sub>-treated group. Significantly, decreased Cl concentrations, and increased Ca and inorganic phosphorus concentrations, were found in the Vit D<sub>3</sub>-treated group. In the Vit D<sub>3</sub> + SEF-treated group, these parameters returned to the levels of the untreated group. In the Vit D<sub>3</sub>-treated group, histopathological examinations showed marked multifocal calcification in the lumens of the renal tubules and the renal parenchyma. The myocardium was replaced by abundant granular mineralization (calcification), with degeneration and necrosis of the calcified fibers. The stomach showed calcification of the cardiac mucosa. SEF treatment remarkably attenuated the Vit D<sub>3</sub>-induced hypervitaminotic injuries. In conclusion, this study provides important evidence that SEF treatment can reduce hypercalcemia and remove calcium deposits from the renal, cardiac, and gastric tissues. SEF treatment is useful in the regulation of disorders caused by an imbalance of serum electrolytes.Tohru KimuraKengo InakaNoboru OgisoMDPI AGarticlecalcificationcardiac musclescomplementary and integrative medicineelectrolytesgastric mucosahistopathologyBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1116, p 1116 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcification cardiac muscles complementary and integrative medicine electrolytes gastric mucosa histopathology Biology (General) QH301-705.5
spellingShingle	calcification cardiac muscles complementary and integrative medicine electrolytes gastric mucosa histopathology Biology (General) QH301-705.5 Tohru Kimura Kengo Inaka Noboru Ogiso Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D<sub>3</sub>-Induced Hypercalcemia
description	The purpose of this study was to elucidate the effects of static electric field (SEF) treatment on vitamin D<sub>3</sub> (Vit D<sub>3</sub>)-induced hypercalcemia and renal calcification in mice. The mice were assigned to three groups: Vit D<sub>3</sub>-treated mice, mice treated with Vit D<sub>3</sub> and SEF (Vit D<sub>3</sub> + SEF), and untreated mice. After the administration of Vit D<sub>3</sub>, the Vit D<sub>3</sub> + SEF-treated mice were exposed to SEF treatment by a high-voltage alternating current over five days. Serum biochemical examinations revealed that both the creatinine and blood urea nitrogen concentrations were significantly higher in the Vit D<sub>3</sub>-treated group. Significantly, decreased Cl concentrations, and increased Ca and inorganic phosphorus concentrations, were found in the Vit D<sub>3</sub>-treated group. In the Vit D<sub>3</sub> + SEF-treated group, these parameters returned to the levels of the untreated group. In the Vit D<sub>3</sub>-treated group, histopathological examinations showed marked multifocal calcification in the lumens of the renal tubules and the renal parenchyma. The myocardium was replaced by abundant granular mineralization (calcification), with degeneration and necrosis of the calcified fibers. The stomach showed calcification of the cardiac mucosa. SEF treatment remarkably attenuated the Vit D<sub>3</sub>-induced hypervitaminotic injuries. In conclusion, this study provides important evidence that SEF treatment can reduce hypercalcemia and remove calcium deposits from the renal, cardiac, and gastric tissues. SEF treatment is useful in the regulation of disorders caused by an imbalance of serum electrolytes.
format	article
author	Tohru Kimura Kengo Inaka Noboru Ogiso
author_facet	Tohru Kimura Kengo Inaka Noboru Ogiso
author_sort	Tohru Kimura
title	Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D<sub>3</sub>-Induced Hypercalcemia
title_short	Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D<sub>3</sub>-Induced Hypercalcemia
title_full	Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D<sub>3</sub>-Induced Hypercalcemia
title_fullStr	Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D<sub>3</sub>-Induced Hypercalcemia
title_full_unstemmed	Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D<sub>3</sub>-Induced Hypercalcemia
title_sort	demonstrative experiment on the favorable effects of static electric field treatment on vitamin d<sub>3</sub>-induced hypercalcemia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d674c753e9cd4c86a387d4f36d4f34a2
work_keys_str_mv	AT tohrukimura demonstrativeexperimentonthefavorableeffectsofstaticelectricfieldtreatmentonvitamindsub3subinducedhypercalcemia AT kengoinaka demonstrativeexperimentonthefavorableeffectsofstaticelectricfieldtreatmentonvitamindsub3subinducedhypercalcemia AT noboruogiso demonstrativeexperimentonthefavorableeffectsofstaticelectricfieldtreatmentonvitamindsub3subinducedhypercalcemia
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Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D<sub>3</sub>-Induced Hypercalcemia

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