The homeobox gene MEIS1 is methylated in BRAF (p.V600E) mutated colon tumors.

The homeobox gene MEIS1 is methylated in BRAF (p.V600E) mutated colon tumors.

Development of colorectal cancer (CRC) can occur both via gene mutations in tumor suppressor genes and oncogenes, as well as via epigenetic changes, including DNA methylation. Site-specific methylation in CRC regulates expression of tumor-associated genes. Right-sided colon tumors more frequently ha...

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Autores principales: Ashwin A Dihal, Arnoud Boot, Eddy H van Roon, Melanie Schrumpf, Arantza Fariña-Sarasqueta, Marta Fiocco, Eliane C M Zeestraten, Peter J K Kuppen, Hans Morreau, Tom van Wezel, Judith M Boer
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d675d3f538cd4653b1f1899bf7926719
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