CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK

The composition of the cytotoxic hexane fraction of the Croton stipuliformis bark was studied by means of a gas chromatography coupled to a mass spectrometry; sesquiterpenes and sterols were characterized as the main constituents. Along with these compounds, three labdane and seco-labdane diterpenoi...

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Autores principales:	Martha S. FRANCO, Claudia P. CORDERO, Fabio ARISTIZABAL, Coralia OSORIO R.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2011
Materias:	<I>Croton stipuliformis</I> Euphorbiaceae labdane MTT assay cytotoxicity. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/d6791a911e3049bbb5d3f6ac70c1b4c8
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spelling	oai:doaj.org-article:d6791a911e3049bbb5d3f6ac70c1b4c82021-11-19T04:13:57ZCYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK0121-40042145-2660https://doaj.org/article/d6791a911e3049bbb5d3f6ac70c1b4c82011-09-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/10067https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The composition of the cytotoxic hexane fraction of the Croton stipuliformis bark was studied by means of a gas chromatography coupled to a mass spectrometry; sesquiterpenes and sterols were characterized as the main constituents. Along with these compounds, three labdane and seco-labdane diterpenoids, 8(17),12E,14-labdatrien-18-oic acid [3], 12E-3,4-seco-labda-4(18),8(17),12,14-tetraen-3-oic acid [2], and its methyl ester [1] were isolated from this fraction through preparative HPLC, and their structures were elucidated by HR-FABMS, 1D and 2D NMR analyses. Additionally, the cytotoxic activity of these three compounds against human tumor cell lines HEp-2, HT-29, MKN-45, MCF-7, and HeLa was assessed. The three compounds showed a non-specific and moderate cytotoxicity against the abovementioned cell lines.Martha S. FRANCOClaudia P. CORDEROFabio ARISTIZABALCoralia OSORIO R.Universidad de Antioquiaarticle<I>Croton stipuliformis</I>EuphorbiaceaelabdaneMTT assaycytotoxicity.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 18, Iss 2 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	<I>Croton stipuliformis</I> Euphorbiaceae labdane MTT assay cytotoxicity. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	<I>Croton stipuliformis</I> Euphorbiaceae labdane MTT assay cytotoxicity. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Martha S. FRANCO Claudia P. CORDERO Fabio ARISTIZABAL Coralia OSORIO R. CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK
description	The composition of the cytotoxic hexane fraction of the Croton stipuliformis bark was studied by means of a gas chromatography coupled to a mass spectrometry; sesquiterpenes and sterols were characterized as the main constituents. Along with these compounds, three labdane and seco-labdane diterpenoids, 8(17),12E,14-labdatrien-18-oic acid [3], 12E-3,4-seco-labda-4(18),8(17),12,14-tetraen-3-oic acid [2], and its methyl ester [1] were isolated from this fraction through preparative HPLC, and their structures were elucidated by HR-FABMS, 1D and 2D NMR analyses. Additionally, the cytotoxic activity of these three compounds against human tumor cell lines HEp-2, HT-29, MKN-45, MCF-7, and HeLa was assessed. The three compounds showed a non-specific and moderate cytotoxicity against the abovementioned cell lines.
format	article
author	Martha S. FRANCO Claudia P. CORDERO Fabio ARISTIZABAL Coralia OSORIO R.
author_facet	Martha S. FRANCO Claudia P. CORDERO Fabio ARISTIZABAL Coralia OSORIO R.
author_sort	Martha S. FRANCO
title	CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK
title_short	CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK
title_full	CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK
title_fullStr	CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK
title_full_unstemmed	CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK
title_sort	cytotoxic labdane diterpenoids isolated from the hexane fraction of the <i>croton stipuliformis</i> stem bark
publisher	Universidad de Antioquia
publishDate	2011
url	https://doaj.org/article/d6791a911e3049bbb5d3f6ac70c1b4c8
work_keys_str_mv	AT marthasfranco cytotoxiclabdanediterpenoidsisolatedfromthehexanefractionoftheicrotonstipuliformisistembark AT claudiapcordero cytotoxiclabdanediterpenoidsisolatedfromthehexanefractionoftheicrotonstipuliformisistembark AT fabioaristizabal cytotoxiclabdanediterpenoidsisolatedfromthehexanefractionoftheicrotonstipuliformisistembark AT coraliaosorior cytotoxiclabdanediterpenoidsisolatedfromthehexanefractionoftheicrotonstipuliformisistembark
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CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE <I>Croton stipuliformis</I> STEM BARK

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