STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE

We have investigated in vivo effects of quercetin dihydrate (QD) upon course of respiratory allergy produced in experimental murine model. To provoke allergy, serum ovalbumin (OVA) was injected at different terms. Following administration of QD at the stage of OVA sensitization, the balance of T-hel...

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Autores principales:	A. O. Kenkishvili, D. Z. Albegova, O. S. Laptev, S. I. Pavlova, G. K. Albegova, I. G. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	flavonoids respiratory allergy immunosuppression Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d67d3d2f18cf4b69aed11cc0a6d0e9c6
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spelling	oai:doaj.org-article:d67d3d2f18cf4b69aed11cc0a6d0e9c62021-11-18T08:03:46ZSTUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE1563-06252313-741X10.15789/1563-0625-2017-5-629-634https://doaj.org/article/d67d3d2f18cf4b69aed11cc0a6d0e9c62017-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1364https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have investigated in vivo effects of quercetin dihydrate (QD) upon course of respiratory allergy produced in experimental murine model. To provoke allergy, serum ovalbumin (OVA) was injected at different terms. Following administration of QD at the stage of OVA sensitization, the balance of T-helper cytokines was changed (IL-2 was decreased along with increased IFNγ) accompanied by decreased allergen-specific IgG1, IgE and increased IgG2a in blood serum. At the stage of boosting the respiratory allergy, intravenous administration of QD caused reduction of inflammatory lung infiltration, and composition of bronchoalveolar lavage fluid was altered, i.e., IgG1 and IgE showed a decrease, along with higher IgG2a levels.A. O. KenkishviliD. Z. AlbegovaO. S. LaptevS. I. PavlovaG. K. AlbegovaI. G. KozlovSPb RAACIarticleflavonoidsrespiratory allergyimmunosuppressionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 5, Pp 629-634 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	flavonoids respiratory allergy immunosuppression Immunologic diseases. Allergy RC581-607
spellingShingle	flavonoids respiratory allergy immunosuppression Immunologic diseases. Allergy RC581-607 A. O. Kenkishvili D. Z. Albegova O. S. Laptev S. I. Pavlova G. K. Albegova I. G. Kozlov STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE
description	We have investigated in vivo effects of quercetin dihydrate (QD) upon course of respiratory allergy produced in experimental murine model. To provoke allergy, serum ovalbumin (OVA) was injected at different terms. Following administration of QD at the stage of OVA sensitization, the balance of T-helper cytokines was changed (IL-2 was decreased along with increased IFNγ) accompanied by decreased allergen-specific IgG1, IgE and increased IgG2a in blood serum. At the stage of boosting the respiratory allergy, intravenous administration of QD caused reduction of inflammatory lung infiltration, and composition of bronchoalveolar lavage fluid was altered, i.e., IgG1 and IgE showed a decrease, along with higher IgG2a levels.
format	article
author	A. O. Kenkishvili D. Z. Albegova O. S. Laptev S. I. Pavlova G. K. Albegova I. G. Kozlov
author_facet	A. O. Kenkishvili D. Z. Albegova O. S. Laptev S. I. Pavlova G. K. Albegova I. G. Kozlov
author_sort	A. O. Kenkishvili
title	STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE
title_short	STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE
title_full	STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE
title_fullStr	STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE
title_full_unstemmed	STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE
title_sort	study of quercetin dihydrate effects in a model of ova-induced respiratory allergy in mice
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/d67d3d2f18cf4b69aed11cc0a6d0e9c6
work_keys_str_mv	AT aokenkishvili studyofquercetindihydrateeffectsinamodelofovainducedrespiratoryallergyinmice AT dzalbegova studyofquercetindihydrateeffectsinamodelofovainducedrespiratoryallergyinmice AT oslaptev studyofquercetindihydrateeffectsinamodelofovainducedrespiratoryallergyinmice AT sipavlova studyofquercetindihydrateeffectsinamodelofovainducedrespiratoryallergyinmice AT gkalbegova studyofquercetindihydrateeffectsinamodelofovainducedrespiratoryallergyinmice AT igkozlov studyofquercetindihydrateeffectsinamodelofovainducedrespiratoryallergyinmice
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STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE

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