Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature

Abstract Background In recent years, numerous studies have reported the development or exacerbation of sarcoidosis due to interferon therapy. However, ocular lesions rarely present as initial symptoms. Herein, we describe a rare case of interferon-α-induced sarcoidosis with uveitis as the initial sy...

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Autores principales:	Ai Kato, Mami Ishihara, Nobuhisa Mizuki
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Interferon Sarcoidosis Uveitis Interferon-induced sarcoidosis Case report Medicine R
Acceso en línea:	https://doaj.org/article/d680fef0ba7543eab26f7d52f5af2963
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spelling	oai:doaj.org-article:d680fef0ba7543eab26f7d52f5af29632021-11-28T12:37:24ZInterferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature10.1186/s13256-021-03181-x1752-1947https://doaj.org/article/d680fef0ba7543eab26f7d52f5af29632021-11-01T00:00:00Zhttps://doi.org/10.1186/s13256-021-03181-xhttps://doaj.org/toc/1752-1947Abstract Background In recent years, numerous studies have reported the development or exacerbation of sarcoidosis due to interferon therapy. However, ocular lesions rarely present as initial symptoms. Herein, we describe a rare case of interferon-α-induced sarcoidosis with uveitis as the initial symptom, and present a review of the relevant literature. Case presentation This case involved a 62-year-old-Japanese woman with a history of a combination treatment of pegylated interferon-α-2a, ribavirin, and simeprevir, after which she developed granulomatous panuveitis. She was subsequently diagnosed with sarcoidosis following histological examination of skin biopsy specimens. In addition to reporting this case, we performed a literature review of 27 cases (24 case reports) of histopathologically diagnosed interferon-α-induced sarcoidosis published between January 2009 and November 2018. Conclusions Among the reviewed cases, 23 (85.1%) cases developed skin lesions and 19 (70.1%) had lung lesions. Only three cases (11.1%) had accompanying eye lesions. Interferon-α therapy was discontinued in 16 cases (52.9%), and the majority exhibited improvement after systemic corticosteroid treatment. There are few reported cases of interferon-α-induced sarcoidosis with uveitis as the initial symptom. However, if uveitis develops during or after interferon-α treatment, it might represent an initial symptom of interferon-α-induced sarcoidosis, as observed in the present case.Ai KatoMami IshiharaNobuhisa MizukiBMCarticleInterferonSarcoidosisUveitisInterferon-induced sarcoidosisCase reportMedicineRENJournal of Medical Case Reports, Vol 15, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Interferon Sarcoidosis Uveitis Interferon-induced sarcoidosis Case report Medicine R
spellingShingle	Interferon Sarcoidosis Uveitis Interferon-induced sarcoidosis Case report Medicine R Ai Kato Mami Ishihara Nobuhisa Mizuki Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature
description	Abstract Background In recent years, numerous studies have reported the development or exacerbation of sarcoidosis due to interferon therapy. However, ocular lesions rarely present as initial symptoms. Herein, we describe a rare case of interferon-α-induced sarcoidosis with uveitis as the initial symptom, and present a review of the relevant literature. Case presentation This case involved a 62-year-old-Japanese woman with a history of a combination treatment of pegylated interferon-α-2a, ribavirin, and simeprevir, after which she developed granulomatous panuveitis. She was subsequently diagnosed with sarcoidosis following histological examination of skin biopsy specimens. In addition to reporting this case, we performed a literature review of 27 cases (24 case reports) of histopathologically diagnosed interferon-α-induced sarcoidosis published between January 2009 and November 2018. Conclusions Among the reviewed cases, 23 (85.1%) cases developed skin lesions and 19 (70.1%) had lung lesions. Only three cases (11.1%) had accompanying eye lesions. Interferon-α therapy was discontinued in 16 cases (52.9%), and the majority exhibited improvement after systemic corticosteroid treatment. There are few reported cases of interferon-α-induced sarcoidosis with uveitis as the initial symptom. However, if uveitis develops during or after interferon-α treatment, it might represent an initial symptom of interferon-α-induced sarcoidosis, as observed in the present case.
format	article
author	Ai Kato Mami Ishihara Nobuhisa Mizuki
author_facet	Ai Kato Mami Ishihara Nobuhisa Mizuki
author_sort	Ai Kato
title	Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature
title_short	Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature
title_full	Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature
title_fullStr	Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature
title_full_unstemmed	Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature
title_sort	interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d680fef0ba7543eab26f7d52f5af2963
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Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature

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