CHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea
Abstract We investigated a multicenter registry to identify estimated event rates according to CHA2DS2-VASc scores in patients with acute ischemic stroke (AIS) and atrial fibrillation (AF). The additional effectiveness of antiplatelets (APs) plus oral anticoagulants (OACs) compared with OACs alone c...
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2021
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oai:doaj.org-article:d68c1d502a9047aa9eacefc8fc0ff1512021-12-02T14:01:23ZCHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea10.1038/s41598-020-80874-12045-2322https://doaj.org/article/d68c1d502a9047aa9eacefc8fc0ff1512021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80874-1https://doaj.org/toc/2045-2322Abstract We investigated a multicenter registry to identify estimated event rates according to CHA2DS2-VASc scores in patients with acute ischemic stroke (AIS) and atrial fibrillation (AF). The additional effectiveness of antiplatelets (APs) plus oral anticoagulants (OACs) compared with OACs alone considering the CHA2DS2-VASc scores was also explored. This study retrospectively analyzed a multicenter stroke registry between Jan 2011 and Nov 2017, identifying patients with acute ischemic stroke with AF. The primary outcome event was a composite of recurrent stroke, myocardial infarction, and all-cause mortality within 1 year. A total of 7395 patients (age, 73 ± 10 years; men, 54.2%) were analyzed. The primary outcome events at one year ranged from 5.99% (95% CI 3.21–8.77) for a CHA2DS2-VASc score of 0 points to 30.45% (95% CI 24.93–35.97) for 7 or more points. After adjustments for covariates, 1-point increases in the CHA2DS2-VASc score consistently increased the risk of primary outcome events (aHR 1.10 [1.06–1.15]) at 1-year. Among OAC-treated patients at discharge (n = 5500), those treated with OAC + AP (vs. OAC alone) were more likely to experience vascular events, though among patients with a CHA2DS2-VASc score of 5 or higher, the risk of primary outcome in the OAC + AP group was comparable to that in the OAC alone group (Pint = 0.01). Our study found that there were significant associations of increasing CHA2DS2-VASc scores with the increasing risk of vascular events at 1-year in AIS with AF. Further study would be warranted.Hak-Loh LeeJoon-Tae KimJi Sung LeeBeom Joon KimJong-Moo ParkKyusik KangSoo Joo LeeJae Guk KimJae-Kwan ChaDae-Hyun KimTai Hwan ParkSang-Soon ParkKyung Bok LeeJun LeeKeun-Sik HongYong-Jin ChoHong-Kyun ParkByung-Chul LeeKyung-Ho YuMi Sun OhDong-Eog KimWi-Sun RyuJay Chol ChoiJee-Hyun KwonWook-Joo KimDong-Ick ShinSung Il SohnJeong-Ho HongMan-Seok ParkKang-Ho ChoiKi-Hyun ChoJuneyoung LeeHee-Joon BaeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Hak-Loh Lee Joon-Tae Kim Ji Sung Lee Beom Joon Kim Jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan Park Sang-Soon Park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-Joo Kim Dong-Ick Shin Sung Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-Joon Bae CHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea |
| description |
Abstract We investigated a multicenter registry to identify estimated event rates according to CHA2DS2-VASc scores in patients with acute ischemic stroke (AIS) and atrial fibrillation (AF). The additional effectiveness of antiplatelets (APs) plus oral anticoagulants (OACs) compared with OACs alone considering the CHA2DS2-VASc scores was also explored. This study retrospectively analyzed a multicenter stroke registry between Jan 2011 and Nov 2017, identifying patients with acute ischemic stroke with AF. The primary outcome event was a composite of recurrent stroke, myocardial infarction, and all-cause mortality within 1 year. A total of 7395 patients (age, 73 ± 10 years; men, 54.2%) were analyzed. The primary outcome events at one year ranged from 5.99% (95% CI 3.21–8.77) for a CHA2DS2-VASc score of 0 points to 30.45% (95% CI 24.93–35.97) for 7 or more points. After adjustments for covariates, 1-point increases in the CHA2DS2-VASc score consistently increased the risk of primary outcome events (aHR 1.10 [1.06–1.15]) at 1-year. Among OAC-treated patients at discharge (n = 5500), those treated with OAC + AP (vs. OAC alone) were more likely to experience vascular events, though among patients with a CHA2DS2-VASc score of 5 or higher, the risk of primary outcome in the OAC + AP group was comparable to that in the OAC alone group (Pint = 0.01). Our study found that there were significant associations of increasing CHA2DS2-VASc scores with the increasing risk of vascular events at 1-year in AIS with AF. Further study would be warranted. |
| format |
article |
| author |
Hak-Loh Lee Joon-Tae Kim Ji Sung Lee Beom Joon Kim Jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan Park Sang-Soon Park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-Joo Kim Dong-Ick Shin Sung Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-Joon Bae |
| author_facet |
Hak-Loh Lee Joon-Tae Kim Ji Sung Lee Beom Joon Kim Jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan Park Sang-Soon Park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-Joo Kim Dong-Ick Shin Sung Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-Joon Bae |
| author_sort |
Hak-Loh Lee |
| title |
CHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea |
| title_short |
CHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea |
| title_full |
CHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea |
| title_fullStr |
CHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea |
| title_full_unstemmed |
CHA2DS2-VASc score in acute ischemic stroke with atrial fibrillation: results from the Clinical Research Collaboration for Stroke in Korea |
| title_sort |
cha2ds2-vasc score in acute ischemic stroke with atrial fibrillation: results from the clinical research collaboration for stroke in korea |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d68c1d502a9047aa9eacefc8fc0ff151 |
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