Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy

Head and neck squamous cell carcinoma (HNSCC) is a relatively widespread cancer with high mortality rates. Many patients with locally advanced disease are treated with combinations of surgery, radiation, and chemotherapy, while others are considered incurable and develop recurrent/metastatic (R/M) d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shalini K. Sureshbabu, Jueelee H. Godbole, Anand Vaibhaw, Shubhada V. Chiplunkar
Formato:	article
Lenguaje:	EN
Publicado:	Open Exploration Publishing Inc. 2021
Materias:	head and neck squamous cell carcinoma tumor microenvironment immunosuppressive network immunotherapy checkpoint inhibitors adoptive transfer of t cells vaccines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d68e38b2b4b0430a969825bdff884e21
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d68e38b2b4b0430a969825bdff884e21
record_format	dspace
spelling	oai:doaj.org-article:d68e38b2b4b0430a969825bdff884e212021-11-24T06:14:34ZImmunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy10.37349/ei.2021.000132768-6655https://doaj.org/article/d68e38b2b4b0430a969825bdff884e212021-08-01T00:00:00Zhttps://www.explorationpub.com/Journals/ei/Article/100313https://doaj.org/toc/2768-6655Head and neck squamous cell carcinoma (HNSCC) is a relatively widespread cancer with high mortality rates. Many patients with locally advanced disease are treated with combinations of surgery, radiation, and chemotherapy, while others are considered incurable and develop recurrent/metastatic (R/M) disease. Despite these treatment modalities, the 5-year survival rate of HNSCC has remained at 50% due to limited treatment options in patients with recurrent disease. Immunotherapy has been shown to induce durable responses in R/M patients, but only a minority of patients currently respond. A major hurdle in tumor immunotherapy is identifying the non-responders and markers to predict resistance in patients who at first responded to the therapy. In HNSCC patients, the tumor microenvironment (TME) assumes a vital role to either diminish or augment immune responses. There is an urgent need for extensive studies to be undertaken to better understand how tumor cells escape immune surveillance and resist immune attack. In this review, the impact of TME on the efficiency of immunotherapy, addressing the factors that mediate therapy resistance are highlighted. The composition of the TME encompassing the immunosuppressive cells including myeloid-derived suppressor cell (MDSC), regulatory T cells (Treg), mesenchymal stem cell (MSC), cancer-associated fibroblast (CAF), and tumor-associated macrophages (TAMs) and intrinsic factors like hypoxia, reactive oxygen species (ROS), extracellular matrix (ECM), angiogenesis, and epithelial-mesenchymal transition (EMT), how this debilitates immunosurveillance, and also discuss existing and potential strategies aimed at targeting these cellular and molecular TME components are reviewed. Understanding the interactions between the TME and immunotherapy is not only important in dissevering the mechanisms of action of immunosuppression but also offers scope for developing newer strategies to improve the competence of current immunotherapies.Shalini K. SureshbabuJueelee H. GodboleAnand VaibhawShubhada V. ChiplunkarOpen Exploration Publishing Inc.articlehead and neck squamous cell carcinomatumor microenvironmentimmunosuppressive networkimmunotherapycheckpoint inhibitorsadoptive transfer of t cellsvaccinesImmunologic diseases. AllergyRC581-607ENExploration of Immunology, Vol 1, Iss 3, Pp 166-198 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	head and neck squamous cell carcinoma tumor microenvironment immunosuppressive network immunotherapy checkpoint inhibitors adoptive transfer of t cells vaccines Immunologic diseases. Allergy RC581-607
spellingShingle	head and neck squamous cell carcinoma tumor microenvironment immunosuppressive network immunotherapy checkpoint inhibitors adoptive transfer of t cells vaccines Immunologic diseases. Allergy RC581-607 Shalini K. Sureshbabu Jueelee H. Godbole Anand Vaibhaw Shubhada V. Chiplunkar Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy
description	Head and neck squamous cell carcinoma (HNSCC) is a relatively widespread cancer with high mortality rates. Many patients with locally advanced disease are treated with combinations of surgery, radiation, and chemotherapy, while others are considered incurable and develop recurrent/metastatic (R/M) disease. Despite these treatment modalities, the 5-year survival rate of HNSCC has remained at 50% due to limited treatment options in patients with recurrent disease. Immunotherapy has been shown to induce durable responses in R/M patients, but only a minority of patients currently respond. A major hurdle in tumor immunotherapy is identifying the non-responders and markers to predict resistance in patients who at first responded to the therapy. In HNSCC patients, the tumor microenvironment (TME) assumes a vital role to either diminish or augment immune responses. There is an urgent need for extensive studies to be undertaken to better understand how tumor cells escape immune surveillance and resist immune attack. In this review, the impact of TME on the efficiency of immunotherapy, addressing the factors that mediate therapy resistance are highlighted. The composition of the TME encompassing the immunosuppressive cells including myeloid-derived suppressor cell (MDSC), regulatory T cells (Treg), mesenchymal stem cell (MSC), cancer-associated fibroblast (CAF), and tumor-associated macrophages (TAMs) and intrinsic factors like hypoxia, reactive oxygen species (ROS), extracellular matrix (ECM), angiogenesis, and epithelial-mesenchymal transition (EMT), how this debilitates immunosurveillance, and also discuss existing and potential strategies aimed at targeting these cellular and molecular TME components are reviewed. Understanding the interactions between the TME and immunotherapy is not only important in dissevering the mechanisms of action of immunosuppression but also offers scope for developing newer strategies to improve the competence of current immunotherapies.
format	article
author	Shalini K. Sureshbabu Jueelee H. Godbole Anand Vaibhaw Shubhada V. Chiplunkar
author_facet	Shalini K. Sureshbabu Jueelee H. Godbole Anand Vaibhaw Shubhada V. Chiplunkar
author_sort	Shalini K. Sureshbabu
title	Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy
title_short	Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy
title_full	Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy
title_fullStr	Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy
title_full_unstemmed	Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy
title_sort	immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy
publisher	Open Exploration Publishing Inc.
publishDate	2021
url	https://doaj.org/article/d68e38b2b4b0430a969825bdff884e21
work_keys_str_mv	AT shaliniksureshbabu immunosuppressivemicroenvironmentinoralcancerimplicationsforcancerimmunotherapy AT jueeleehgodbole immunosuppressivemicroenvironmentinoralcancerimplicationsforcancerimmunotherapy AT anandvaibhaw immunosuppressivemicroenvironmentinoralcancerimplicationsforcancerimmunotherapy AT shubhadavchiplunkar immunosuppressivemicroenvironmentinoralcancerimplicationsforcancerimmunotherapy
_version_	1718415946744332288

Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy

Ejemplares similares