Long Non-Coding RNAs in Brown Adipose Tissue

Songjia Lai,1,* Kun Du,1,* Yu Shi,1 Cao Li,1 Guoze Wang,1,2 Shenqiang Hu,1 Xianbo Jia,1 Jie Wang,1 Shiyi Chen1 1Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, People’s Republic of China; 2The Key...

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Autores principales:	Lai S, Du K, Shi Y, Li C, Wang G, Hu S, Jia X, Wang J, Chen S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	obesity bat thermogenesis lncrnas Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d68ec717c60f49959595730899b182f6
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spelling	oai:doaj.org-article:d68ec717c60f49959595730899b182f62021-12-02T11:23:06ZLong Non-Coding RNAs in Brown Adipose Tissue1178-7007https://doaj.org/article/d68ec717c60f49959595730899b182f62020-09-01T00:00:00Zhttps://www.dovepress.com/long-non-coding-rnas-in-brown-adipose-tissue-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Songjia Lai,1,* Kun Du,1,* Yu Shi,1 Cao Li,1 Guoze Wang,1,2 Shenqiang Hu,1 Xianbo Jia,1 Jie Wang,1 Shiyi Chen1 1Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, People’s Republic of China; 2The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, People’s Republic of China*These authors contributed equally to this workCorrespondence: Songjia LaiFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, 211# Huimin Road, Wenjiang 611130, Sichuan, People’s Republic of ChinaEmail laisj5794@163.comAbstract: Obesity has become a widespread disease that is harmful to human health. Fat homeostasis is essentially maintained by fat accumulation and energy expenditure. Studies on brown adipose tissue (BAT) represent a promising opportunity to identify a pharmaceutical intervention against obesity through increased energy expenditure. Long non-coding RNAs (lncRNAs) were thought to be critical regulators in a variety of biological processes. Recent studies have revealed that lncRNAs, including ones that are BAT-specific, conserved, and located at key protein-coding genes, function in brown adipogenesis, white adipose browning (ie, beige adipogenesis), and brown thermogenesis. In this review, we describe lncRNA properties and highlight functional lncRNAs in these biological processes, with the goal of establishing links between lncRNAs and BAT. Based on the advances of lncRNAs in the regulation of BAT, we discussed the advantages of potential lncRNA-based obesity drugs. Further BAT lncRNA-based drug development may provide new exciting approaches to defend obesity by regulation of fat homeostasis.Keywords: obesity, BAT, thermogenesis, lncRNAsLai SDu KShi YLi CWang GHu SJia XWang JChen SDove Medical PressarticleobesitybatthermogenesislncrnasSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3193-3204 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity bat thermogenesis lncrnas Specialties of internal medicine RC581-951
spellingShingle	obesity bat thermogenesis lncrnas Specialties of internal medicine RC581-951 Lai S Du K Shi Y Li C Wang G Hu S Jia X Wang J Chen S Long Non-Coding RNAs in Brown Adipose Tissue
description	Songjia Lai,1,* Kun Du,1,* Yu Shi,1 Cao Li,1 Guoze Wang,1,2 Shenqiang Hu,1 Xianbo Jia,1 Jie Wang,1 Shiyi Chen1 1Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, People’s Republic of China; 2The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, People’s Republic of China*These authors contributed equally to this workCorrespondence: Songjia LaiFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, 211# Huimin Road, Wenjiang 611130, Sichuan, People’s Republic of ChinaEmail laisj5794@163.comAbstract: Obesity has become a widespread disease that is harmful to human health. Fat homeostasis is essentially maintained by fat accumulation and energy expenditure. Studies on brown adipose tissue (BAT) represent a promising opportunity to identify a pharmaceutical intervention against obesity through increased energy expenditure. Long non-coding RNAs (lncRNAs) were thought to be critical regulators in a variety of biological processes. Recent studies have revealed that lncRNAs, including ones that are BAT-specific, conserved, and located at key protein-coding genes, function in brown adipogenesis, white adipose browning (ie, beige adipogenesis), and brown thermogenesis. In this review, we describe lncRNA properties and highlight functional lncRNAs in these biological processes, with the goal of establishing links between lncRNAs and BAT. Based on the advances of lncRNAs in the regulation of BAT, we discussed the advantages of potential lncRNA-based obesity drugs. Further BAT lncRNA-based drug development may provide new exciting approaches to defend obesity by regulation of fat homeostasis.Keywords: obesity, BAT, thermogenesis, lncRNAs
format	article
author	Lai S Du K Shi Y Li C Wang G Hu S Jia X Wang J Chen S
author_facet	Lai S Du K Shi Y Li C Wang G Hu S Jia X Wang J Chen S
author_sort	Lai S
title	Long Non-Coding RNAs in Brown Adipose Tissue
title_short	Long Non-Coding RNAs in Brown Adipose Tissue
title_full	Long Non-Coding RNAs in Brown Adipose Tissue
title_fullStr	Long Non-Coding RNAs in Brown Adipose Tissue
title_full_unstemmed	Long Non-Coding RNAs in Brown Adipose Tissue
title_sort	long non-coding rnas in brown adipose tissue
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d68ec717c60f49959595730899b182f6
work_keys_str_mv	AT lais longnoncodingrnasinbrownadiposetissue AT duk longnoncodingrnasinbrownadiposetissue AT shiy longnoncodingrnasinbrownadiposetissue AT lic longnoncodingrnasinbrownadiposetissue AT wangg longnoncodingrnasinbrownadiposetissue AT hus longnoncodingrnasinbrownadiposetissue AT jiax longnoncodingrnasinbrownadiposetissue AT wangj longnoncodingrnasinbrownadiposetissue AT chens longnoncodingrnasinbrownadiposetissue
_version_	1718395966379261952

Long Non-Coding RNAs in Brown Adipose Tissue

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