Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect

Niacinamide (NIA) has been widely used in halting the features of ageing by acting as an antioxidant and preventing dehydration. NIA’s physicochemical properties suggest difficulties in surpassing the barrier imposed by the stratum corneum layer to reach the target in the skin. To improve cutaneous...

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Autores principales:	Renata Basto, Raquel Andrade, Cláudia Nunes, Sofia A. Costa Lima, Salette Reis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	in vitro release jojoba oil oleic acid permeation enhancers transethosomes tween 80 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d69039f80c0543cd9ae4ede19fd7e05f
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spelling	oai:doaj.org-article:d69039f80c0543cd9ae4ede19fd7e05f2021-11-25T18:42:29ZTopical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect10.3390/pharmaceutics131119681999-4923https://doaj.org/article/d69039f80c0543cd9ae4ede19fd7e05f2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1968https://doaj.org/toc/1999-4923Niacinamide (NIA) has been widely used in halting the features of ageing by acting as an antioxidant and preventing dehydration. NIA’s physicochemical properties suggest difficulties in surpassing the barrier imposed by the stratum corneum layer to reach the target in the skin. To improve cutaneous delivery of NIA, a hybrid nanogel was designed using carrageenan and polyvinylpyrrolidone polymers combined with jojoba oil as a permeation enhancer. Three different types of transethosomes were prepared by the thin-film hydration method, made distinct by the presence of either an edge activator or a permeation enhancer, to allow for a controlled delivery of NIA. Formulations were characterized by measurements of size, polydispersity index, zeta potential, encapsulation efficiency, and loading capacity, and by evaluating their chemical interactions and morphology. Skin permeation assays were performed using Franz diffusion cells. The hybrid hydrogels exhibited robust, porous, and highly aligned macrostructures, and when present, jojoba oil changed their morphology. Skin permeation studies with transethosomes-loaded hydrogels showed that nanogels per se exhibit a more controlled and enhanced permeation, in particular when jojoba oil was present in the transethosomes. These promising nanogels protected the human keratinocytes from UV radiation, and thus can be added to sunscreens or after-sun lotions to improve skin protection.Renata BastoRaquel AndradeCláudia NunesSofia A. Costa LimaSalette ReisMDPI AGarticlein vitro releasejojoba oiloleic acidpermeation enhancerstransethosomestween 80Pharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1968, p 1968 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	in vitro release jojoba oil oleic acid permeation enhancers transethosomes tween 80 Pharmacy and materia medica RS1-441
spellingShingle	in vitro release jojoba oil oleic acid permeation enhancers transethosomes tween 80 Pharmacy and materia medica RS1-441 Renata Basto Raquel Andrade Cláudia Nunes Sofia A. Costa Lima Salette Reis Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect
description	Niacinamide (NIA) has been widely used in halting the features of ageing by acting as an antioxidant and preventing dehydration. NIA’s physicochemical properties suggest difficulties in surpassing the barrier imposed by the stratum corneum layer to reach the target in the skin. To improve cutaneous delivery of NIA, a hybrid nanogel was designed using carrageenan and polyvinylpyrrolidone polymers combined with jojoba oil as a permeation enhancer. Three different types of transethosomes were prepared by the thin-film hydration method, made distinct by the presence of either an edge activator or a permeation enhancer, to allow for a controlled delivery of NIA. Formulations were characterized by measurements of size, polydispersity index, zeta potential, encapsulation efficiency, and loading capacity, and by evaluating their chemical interactions and morphology. Skin permeation assays were performed using Franz diffusion cells. The hybrid hydrogels exhibited robust, porous, and highly aligned macrostructures, and when present, jojoba oil changed their morphology. Skin permeation studies with transethosomes-loaded hydrogels showed that nanogels per se exhibit a more controlled and enhanced permeation, in particular when jojoba oil was present in the transethosomes. These promising nanogels protected the human keratinocytes from UV radiation, and thus can be added to sunscreens or after-sun lotions to improve skin protection.
format	article
author	Renata Basto Raquel Andrade Cláudia Nunes Sofia A. Costa Lima Salette Reis
author_facet	Renata Basto Raquel Andrade Cláudia Nunes Sofia A. Costa Lima Salette Reis
author_sort	Renata Basto
title	Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect
title_short	Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect
title_full	Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect
title_fullStr	Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect
title_full_unstemmed	Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect
title_sort	topical delivery of niacinamide to skin using hybrid nanogels enhances photoprotection effect
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d69039f80c0543cd9ae4ede19fd7e05f
work_keys_str_mv	AT renatabasto topicaldeliveryofniacinamidetoskinusinghybridnanogelsenhancesphotoprotectioneffect AT raquelandrade topicaldeliveryofniacinamidetoskinusinghybridnanogelsenhancesphotoprotectioneffect AT claudianunes topicaldeliveryofniacinamidetoskinusinghybridnanogelsenhancesphotoprotectioneffect AT sofiaacostalima topicaldeliveryofniacinamidetoskinusinghybridnanogelsenhancesphotoprotectioneffect AT salettereis topicaldeliveryofniacinamidetoskinusinghybridnanogelsenhancesphotoprotectioneffect
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Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect

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