Modern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne

Background. Acne has a net detrimental effect on the quality of life of patients, which is due not only to long-term treatment and predominance of dermatosis on the face, but also due to substantial risk of development of enduring post-inflammatory skin changes. The main part of treatment methods fo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marina M. Tlish, Marina E. Shavilova
Formato:	article
Lenguaje:	RU
Publicado:	State Scientific Center of Dermatovenereology and Cosmetology 2021
Materias:	acne post-acne marks post-inflammatory skin changes Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/d6913111043646bc97140d3ccf64101e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d6913111043646bc97140d3ccf64101e
record_format	dspace
spelling	oai:doaj.org-article:d6913111043646bc97140d3ccf64101e2021-12-01T22:16:30ZModern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne0042-46092313-629410.25208/vdv1241https://doaj.org/article/d6913111043646bc97140d3ccf64101e2021-10-01T00:00:00Zhttps://vestnikdv.ru/jour/article/viewFile/1241/1237https://doaj.org/toc/0042-4609https://doaj.org/toc/2313-6294Background. Acne has a net detrimental effect on the quality of life of patients, which is due not only to long-term treatment and predominance of dermatosis on the face, but also due to substantial risk of development of enduring post-inflammatory skin changes. The main part of treatment methods for post-acne marks is currently aimed at correction of already formed rash, and not at prevention of its development. In this respect, studies aimed at development of new methods for prevention and treatment of post-inflammatory skin changes in acne are particularly topical. Aim. To evaluate clinical efficiency and tolerability of Postacnetin gel at prevention and correction of significant post-inflammatory skin changes in patients with severe forms of acne vulgaris. Methods. 60 patients with severe forms of acne were under observation and were prescribed isotretinoin and topical medications in accordance with the Federal Guidelines of Treatment. Depending on the planned supporting therapy, the patients were divided into main and control groups of 30 people. Patients of the control group used only adapalene cream after the end of the course of systemic treatment with isotretinoin. Patients of the main group were additionally prescribed Postacnetin gel 2 months before reaching the cumulated dose of isotretinoin, and were also recommended to use it within 4 months after termination of isotretinoin therapy alongside with the use of adapalene cream. The effect of Postacnetin gel on post-inflammatory skin changes was assessed over time by counting post-acne elements, mexametry data and results of assessment of cicatrical changes according to the scale of G. Goodmann et al. Tolerability of the therapy was studied by means of monitoring of adverse reactions and calculation of the dermatology life quality index (DLQI). Results. By the end of application of the systemic medication, persistent erythema developed less often in patients of the main group, and pigmentation and scars were clinically less severe according to the data of the mexametry and the scale of G. Goodman et al. Subsequent dynamic observation of patients of the main group revealed more significant regression of post-inflammatory changes in them. Thus, dark spots were less common in these patients in the 2nd and 4th months in comparison with the control group, and according to mexametry data, they were less severe. They also had lower severity of scars and level of the total index of the quantitative scale of G. Goodman et al. According to the results of monitoring of side effects and DLQI, both treatment regimens were well tolerated. Conclusion. The use of Postacnetin gel in the complex therapy of patients with severe forms of acne vulgaris is an effective method for prevention and correction of persistent post-inflammatory skin changes and is well tolerated by patients.Marina M. TlishMarina E. ShavilovaState Scientific Center of Dermatovenereology and Cosmetologyarticleacnepost-acne markspost-inflammatory skin changesDermatologyRL1-803RUVestnik Dermatologii i Venerologii, Vol 97, Iss 4, Pp 92-99 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	acne post-acne marks post-inflammatory skin changes Dermatology RL1-803
spellingShingle	acne post-acne marks post-inflammatory skin changes Dermatology RL1-803 Marina M. Tlish Marina E. Shavilova Modern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne
description	Background. Acne has a net detrimental effect on the quality of life of patients, which is due not only to long-term treatment and predominance of dermatosis on the face, but also due to substantial risk of development of enduring post-inflammatory skin changes. The main part of treatment methods for post-acne marks is currently aimed at correction of already formed rash, and not at prevention of its development. In this respect, studies aimed at development of new methods for prevention and treatment of post-inflammatory skin changes in acne are particularly topical. Aim. To evaluate clinical efficiency and tolerability of Postacnetin gel at prevention and correction of significant post-inflammatory skin changes in patients with severe forms of acne vulgaris. Methods. 60 patients with severe forms of acne were under observation and were prescribed isotretinoin and topical medications in accordance with the Federal Guidelines of Treatment. Depending on the planned supporting therapy, the patients were divided into main and control groups of 30 people. Patients of the control group used only adapalene cream after the end of the course of systemic treatment with isotretinoin. Patients of the main group were additionally prescribed Postacnetin gel 2 months before reaching the cumulated dose of isotretinoin, and were also recommended to use it within 4 months after termination of isotretinoin therapy alongside with the use of adapalene cream. The effect of Postacnetin gel on post-inflammatory skin changes was assessed over time by counting post-acne elements, mexametry data and results of assessment of cicatrical changes according to the scale of G. Goodmann et al. Tolerability of the therapy was studied by means of monitoring of adverse reactions and calculation of the dermatology life quality index (DLQI). Results. By the end of application of the systemic medication, persistent erythema developed less often in patients of the main group, and pigmentation and scars were clinically less severe according to the data of the mexametry and the scale of G. Goodman et al. Subsequent dynamic observation of patients of the main group revealed more significant regression of post-inflammatory changes in them. Thus, dark spots were less common in these patients in the 2nd and 4th months in comparison with the control group, and according to mexametry data, they were less severe. They also had lower severity of scars and level of the total index of the quantitative scale of G. Goodman et al. According to the results of monitoring of side effects and DLQI, both treatment regimens were well tolerated. Conclusion. The use of Postacnetin gel in the complex therapy of patients with severe forms of acne vulgaris is an effective method for prevention and correction of persistent post-inflammatory skin changes and is well tolerated by patients.
format	article
author	Marina M. Tlish Marina E. Shavilova
author_facet	Marina M. Tlish Marina E. Shavilova
author_sort	Marina M. Tlish
title	Modern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne
title_short	Modern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne
title_full	Modern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne
title_fullStr	Modern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne
title_full_unstemmed	Modern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne
title_sort	modern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne
publisher	State Scientific Center of Dermatovenereology and Cosmetology
publishDate	2021
url	https://doaj.org/article/d6913111043646bc97140d3ccf64101e
work_keys_str_mv	AT marinamtlish modernpossibilitiesofasupportingtherapyandcorrectionofpostinflammatoryskinchangesinpatientswithacne AT marinaeshavilova modernpossibilitiesofasupportingtherapyandcorrectionofpostinflammatoryskinchangesinpatientswithacne
_version_	1718404128974045184

Modern possibilities of a supporting therapy and correction of post-inflammatory skin changes in patients with acne

Ejemplares similares