Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose

Abstract Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson’s disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly understood. Normally, movements depend on the...

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Autores principales:	Noham Wolpe, Jiaxiang Zhang, Cristina Nombela, James N. Ingram, Daniel M. Wolpert, Cam-CAN, James B. Rowe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Sensory Attenuation Dose Dopamine Target Force Sensorimotor Prediction Levodopa Equivalent Dose (LDE) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6926e5759234e37898a9275b79364e2
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spelling	oai:doaj.org-article:d6926e5759234e37898a9275b79364e22021-12-02T11:40:54ZSensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose10.1038/s41598-018-33678-32045-2322https://doaj.org/article/d6926e5759234e37898a9275b79364e22018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33678-3https://doaj.org/toc/2045-2322Abstract Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson’s disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly understood. Normally, movements depend on the integration of sensory information with the predicted consequences of action. This integration leads to a suppression in the intensity of predicted sensations, reflected in a ‘sensory attenuation’. We examined this integration process and its relation to dopamine in PD, by measuring sensory attenuation. Patients with idiopathic PD (n = 18) and population-derived controls (n = 175) matched a set of target forces applied to their left index finger by a torque motor. To match the force, participants either pressed with their right index finger (‘Direct’ condition) or moved a knob that controlled a motor through a linear potentiometer (‘Slider’ condition). We found that despite changes in sensitivity to different forces, overall sensory attenuation did not differ between medicated PD patients and controls. Importantly, the degree of attenuation was negatively related to PD motor severity but positively related to individual patient dopamine dose, as measured by levodopa dose equivalent. The results suggest that dopamine could regulate the integration of sensorimotor prediction with sensory information to facilitate the control of voluntary movements.Noham WolpeJiaxiang ZhangCristina NombelaJames N. IngramDaniel M. WolpertCam-CANJames B. RoweNature PortfolioarticleSensory AttenuationDose DopamineTarget ForceSensorimotor PredictionLevodopa Equivalent Dose (LDE)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sensory Attenuation Dose Dopamine Target Force Sensorimotor Prediction Levodopa Equivalent Dose (LDE) Medicine R Science Q
spellingShingle	Sensory Attenuation Dose Dopamine Target Force Sensorimotor Prediction Levodopa Equivalent Dose (LDE) Medicine R Science Q Noham Wolpe Jiaxiang Zhang Cristina Nombela James N. Ingram Daniel M. Wolpert Cam-CAN James B. Rowe Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose
description	Abstract Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson’s disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly understood. Normally, movements depend on the integration of sensory information with the predicted consequences of action. This integration leads to a suppression in the intensity of predicted sensations, reflected in a ‘sensory attenuation’. We examined this integration process and its relation to dopamine in PD, by measuring sensory attenuation. Patients with idiopathic PD (n = 18) and population-derived controls (n = 175) matched a set of target forces applied to their left index finger by a torque motor. To match the force, participants either pressed with their right index finger (‘Direct’ condition) or moved a knob that controlled a motor through a linear potentiometer (‘Slider’ condition). We found that despite changes in sensitivity to different forces, overall sensory attenuation did not differ between medicated PD patients and controls. Importantly, the degree of attenuation was negatively related to PD motor severity but positively related to individual patient dopamine dose, as measured by levodopa dose equivalent. The results suggest that dopamine could regulate the integration of sensorimotor prediction with sensory information to facilitate the control of voluntary movements.
format	article
author	Noham Wolpe Jiaxiang Zhang Cristina Nombela James N. Ingram Daniel M. Wolpert Cam-CAN James B. Rowe
author_facet	Noham Wolpe Jiaxiang Zhang Cristina Nombela James N. Ingram Daniel M. Wolpert Cam-CAN James B. Rowe
author_sort	Noham Wolpe
title	Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose
title_short	Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose
title_full	Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose
title_fullStr	Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose
title_full_unstemmed	Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose
title_sort	sensory attenuation in parkinson’s disease is related to disease severity and dopamine dose
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d6926e5759234e37898a9275b79364e2
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Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose

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