Role of CD44 as a marker of cancer stem cells in head and neck cancer

Serena Trapasso, Eugenia AllegraOtolaryngology &ndash; Head and Neck Surgery, University Magna Graecia of Catanzaro, Catanzaro, ItalyAbstract: In recent years, many studies have shown that some types of tumors are characterized by the presence of cells with stem-like characteristics, called...

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Autores principales:	Trapasso S, Allegra E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d693ae093c7844839dba85f47659d35d
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spelling	oai:doaj.org-article:d693ae093c7844839dba85f47659d35d2021-12-02T01:02:16ZRole of CD44 as a marker of cancer stem cells in head and neck cancer1177-54751177-5491https://doaj.org/article/d693ae093c7844839dba85f47659d35d2012-11-01T00:00:00Zhttp://www.dovepress.com/role-of-cd44-as-a-marker-of-cancer-stem-cells-in-head-and-neck-cancer-a11415https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Serena Trapasso, Eugenia AllegraOtolaryngology &ndash; Head and Neck Surgery, University Magna Graecia of Catanzaro, Catanzaro, ItalyAbstract: In recent years, many studies have shown that some types of tumors are characterized by the presence of cells with stem-like characteristics, called cancer stem cells (CSCs). These are considered cells that initiate the tumor and are probably responsible for tumor recurrence. CSCs have the capacity for self-renewal, the potential to give rise to one or more cell types within the tumor, and the ability to drive, in a continuous manner, the proliferation of malignant cells. The failure of current cancer therapies can be attributed to the relative ineffectiveness of drugs against CSCs, which remain viable while retaining their full ability to reproduce the tumor. The development of new strategies is currently hampered by the lack of reliable markers to identify CSCs. One promising surface marker of CSCs in head and neck cancer is the CD44 molecule, which has been shown in preliminary studies to have high specificity, although there are discrepant data because its prognostic value may depend on the specific tumor location. More rigorous studies are needed to investigate the usefulness of CD44 expression in head and neck tumors for possible clinical applicability.Keywords: CD44, head and neck squamous cell carcinoma, cancer stem cellsTrapasso SAllegra EDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2012, Iss default, Pp 379-383 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Trapasso S Allegra E Role of CD44 as a marker of cancer stem cells in head and neck cancer
description	Serena Trapasso, Eugenia AllegraOtolaryngology &ndash; Head and Neck Surgery, University Magna Graecia of Catanzaro, Catanzaro, ItalyAbstract: In recent years, many studies have shown that some types of tumors are characterized by the presence of cells with stem-like characteristics, called cancer stem cells (CSCs). These are considered cells that initiate the tumor and are probably responsible for tumor recurrence. CSCs have the capacity for self-renewal, the potential to give rise to one or more cell types within the tumor, and the ability to drive, in a continuous manner, the proliferation of malignant cells. The failure of current cancer therapies can be attributed to the relative ineffectiveness of drugs against CSCs, which remain viable while retaining their full ability to reproduce the tumor. The development of new strategies is currently hampered by the lack of reliable markers to identify CSCs. One promising surface marker of CSCs in head and neck cancer is the CD44 molecule, which has been shown in preliminary studies to have high specificity, although there are discrepant data because its prognostic value may depend on the specific tumor location. More rigorous studies are needed to investigate the usefulness of CD44 expression in head and neck tumors for possible clinical applicability.Keywords: CD44, head and neck squamous cell carcinoma, cancer stem cells
format	article
author	Trapasso S Allegra E
author_facet	Trapasso S Allegra E
author_sort	Trapasso S
title	Role of CD44 as a marker of cancer stem cells in head and neck cancer
title_short	Role of CD44 as a marker of cancer stem cells in head and neck cancer
title_full	Role of CD44 as a marker of cancer stem cells in head and neck cancer
title_fullStr	Role of CD44 as a marker of cancer stem cells in head and neck cancer
title_full_unstemmed	Role of CD44 as a marker of cancer stem cells in head and neck cancer
title_sort	role of cd44 as a marker of cancer stem cells in head and neck cancer
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/d693ae093c7844839dba85f47659d35d
work_keys_str_mv	AT trapassos roleofcd44asamarkerofcancerstemcellsinheadandneckcancer AT allegrae roleofcd44asamarkerofcancerstemcellsinheadandneckcancer
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Role of CD44 as a marker of cancer stem cells in head and neck cancer

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