Mutation induced conformational changes in genomic DNA from cancerous K562 cells influence drug-DNA binding modes.

Mutation induced conformational changes in genomic DNA from cancerous K562 cells influence drug-DNA binding modes.

Normal human genomic DNA (N-DNA) and mutated DNA (M-DNA) from K562 leukemic cells show different thermodynamic properties and binding affinities on interaction with anticancer drugs; adriamycin (ADR) and daunomycin (DNM). Isothermal calorimetric thermograms representing titration of ADR/DNM with N-D...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Debjani Ghosh, Subrata Kumar Dey, Chabita Saha
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d696a1ae2f614b448ebfe5c5442c6657
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares