Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2.

Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2.

<h4>Background</h4>The Conditional by Inversion (COIN) method for engineering conditional alleles relies on an invertible optimized gene trap-like element, the COIN module, for imparting conditionality. The COIN module contains an optimized 3' splice site-polyadenylation signal pair...

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Autores principales: Nikolaos Mandalos, Marannia Saridaki, Jessica Lea Harper, Anastasia Kotsoni, Peter Yang, Aris N Economides, Eumorphia Remboutsika
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d6976246591948b8898880b6fa1905b6
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