A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

Influenza B virus (IBV) co-circulates with influenza A virus to cause annual epidemics. Here, Chaiet al. isolate a human monoclonal antibody that binds to a conserved epitope in the viral HA protein, neutralizes IBV strains in vitro, and protects mice against IBV infection.

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Autores principales: Ning Chai, Lee R. Swem, Summer Park, Gerald Nakamura, Nancy Chiang, Alberto Estevez, Rina Fong, Lynn Kamen, Elviza Kho, Mike Reichelt, Zhonghua Lin, Henry Chiu, Elizabeth Skippington, Zora Modrusan, Jeremy Stinson, Min Xu, Patrick Lupardus, Claudio Ciferri, Man-Wah Tan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d697ead9ca194b4d8f53f1f10eadf047
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spelling oai:doaj.org-article:d697ead9ca194b4d8f53f1f10eadf0472021-12-02T17:06:16ZA broadly protective therapeutic antibody against influenza B virus with two mechanisms of action10.1038/ncomms142342041-1723https://doaj.org/article/d697ead9ca194b4d8f53f1f10eadf0472017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14234https://doaj.org/toc/2041-1723Influenza B virus (IBV) co-circulates with influenza A virus to cause annual epidemics. Here, Chaiet al. isolate a human monoclonal antibody that binds to a conserved epitope in the viral HA protein, neutralizes IBV strains in vitro, and protects mice against IBV infection.Ning ChaiLee R. SwemSummer ParkGerald NakamuraNancy ChiangAlberto EstevezRina FongLynn KamenElviza KhoMike ReicheltZhonghua LinHenry ChiuElizabeth SkippingtonZora ModrusanJeremy StinsonMin XuPatrick LupardusClaudio CiferriMan-Wah TanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ning Chai
Lee R. Swem
Summer Park
Gerald Nakamura
Nancy Chiang
Alberto Estevez
Rina Fong
Lynn Kamen
Elviza Kho
Mike Reichelt
Zhonghua Lin
Henry Chiu
Elizabeth Skippington
Zora Modrusan
Jeremy Stinson
Min Xu
Patrick Lupardus
Claudio Ciferri
Man-Wah Tan
A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
description Influenza B virus (IBV) co-circulates with influenza A virus to cause annual epidemics. Here, Chaiet al. isolate a human monoclonal antibody that binds to a conserved epitope in the viral HA protein, neutralizes IBV strains in vitro, and protects mice against IBV infection.
format article
author Ning Chai
Lee R. Swem
Summer Park
Gerald Nakamura
Nancy Chiang
Alberto Estevez
Rina Fong
Lynn Kamen
Elviza Kho
Mike Reichelt
Zhonghua Lin
Henry Chiu
Elizabeth Skippington
Zora Modrusan
Jeremy Stinson
Min Xu
Patrick Lupardus
Claudio Ciferri
Man-Wah Tan
author_facet Ning Chai
Lee R. Swem
Summer Park
Gerald Nakamura
Nancy Chiang
Alberto Estevez
Rina Fong
Lynn Kamen
Elviza Kho
Mike Reichelt
Zhonghua Lin
Henry Chiu
Elizabeth Skippington
Zora Modrusan
Jeremy Stinson
Min Xu
Patrick Lupardus
Claudio Ciferri
Man-Wah Tan
author_sort Ning Chai
title A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
title_short A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
title_full A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
title_fullStr A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
title_full_unstemmed A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
title_sort broadly protective therapeutic antibody against influenza b virus with two mechanisms of action
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/d697ead9ca194b4d8f53f1f10eadf047
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