Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons

Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is unusual because it has restricted expression in the nervous system and is the only membrane-bound PRMT. Emerging studies have demonstrated that this enzyme plays multifaceted roles in diverse processes in neurons. Here we...

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Autores principales:	Rui Dong, Xuejun Li, Kwok-On Lai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neuron synapse dendritic spine actin cytoskeleton GTPase post-translational modification Science Q
Acceso en línea:	https://doaj.org/article/d698f958ba154a6cadb35054e532f620
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spelling	oai:doaj.org-article:d698f958ba154a6cadb35054e532f6202021-11-25T18:10:32ZActivity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons10.3390/life111111322075-1729https://doaj.org/article/d698f958ba154a6cadb35054e532f6202021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1132https://doaj.org/toc/2075-1729Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is unusual because it has restricted expression in the nervous system and is the only membrane-bound PRMT. Emerging studies have demonstrated that this enzyme plays multifaceted roles in diverse processes in neurons. Here we will summarize the unique structural features of PRMT8 and describe how it participates in various neuronal functions such as dendritic growth, synapse maturation, and synaptic plasticity. Recent evidence suggesting the potential role of PRMT8 function in neurological diseases will also be discussed.Rui DongXuejun LiKwok-On LaiMDPI AGarticleneuronsynapsedendritic spineactin cytoskeletonGTPasepost-translational modificationScienceQENLife, Vol 11, Iss 1132, p 1132 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuron synapse dendritic spine actin cytoskeleton GTPase post-translational modification Science Q
spellingShingle	neuron synapse dendritic spine actin cytoskeleton GTPase post-translational modification Science Q Rui Dong Xuejun Li Kwok-On Lai Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
description	Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is unusual because it has restricted expression in the nervous system and is the only membrane-bound PRMT. Emerging studies have demonstrated that this enzyme plays multifaceted roles in diverse processes in neurons. Here we will summarize the unique structural features of PRMT8 and describe how it participates in various neuronal functions such as dendritic growth, synapse maturation, and synaptic plasticity. Recent evidence suggesting the potential role of PRMT8 function in neurological diseases will also be discussed.
format	article
author	Rui Dong Xuejun Li Kwok-On Lai
author_facet	Rui Dong Xuejun Li Kwok-On Lai
author_sort	Rui Dong
title	Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_short	Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_full	Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_fullStr	Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_full_unstemmed	Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
title_sort	activity and function of the prmt8 protein arginine methyltransferase in neurons
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d698f958ba154a6cadb35054e532f620
work_keys_str_mv	AT ruidong activityandfunctionoftheprmt8proteinargininemethyltransferaseinneurons AT xuejunli activityandfunctionoftheprmt8proteinargininemethyltransferaseinneurons AT kwokonlai activityandfunctionoftheprmt8proteinargininemethyltransferaseinneurons
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Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons

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