Epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.

<h4>Background</h4>Alcohol dependence during withdrawal and also in abstinent period in many cases is related to reduced inhibitory functions and kindling that may appear in the form of psychosensory symptoms similar to temporal lobe epilepsy frequently in conditions of normal EEG and wi...

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Autores principales:	Petr Bob, Denisa Jasova, Gustav Bizik, Jiri Raboch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d69916ae618c4872836cd66510b4ca8b
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spelling	oai:doaj.org-article:d69916ae618c4872836cd66510b4ca8b2021-11-18T06:55:10ZEpileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.1932-620310.1371/journal.pone.0018678https://doaj.org/article/d69916ae618c4872836cd66510b4ca8b2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21541318/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Alcohol dependence during withdrawal and also in abstinent period in many cases is related to reduced inhibitory functions and kindling that may appear in the form of psychosensory symptoms similar to temporal lobe epilepsy frequently in conditions of normal EEG and without seizures. Because temporal lobe epileptic activity tend to spread between hemispheres, it is possible to suppose that measures reflecting interhemispheric information transfer such as electrodermal activity (EDA) might be related to the psychosensory symptoms.<h4>Methods and findings</h4>We have performed measurement of bilateral EDA, psychosensory symptoms (LSCL-33) and alcohol craving (ACQ) in 34 alcohol dependent patients and 32 healthy controls. The results in alcohol dependent patients show that during rest conditions the psychosensory symptoms (LSCL-33) are related to EDA transinformation (PTI) between left and right EDA records (Spearman r = 0.44, p<0.01).<h4>Conclusions</h4>The result may present potentially useful clinical finding suggesting a possibility to indirectly assess epileptiform changes in alcohol dependent patients.Petr BobDenisa JasovaGustav BizikJiri RabochPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18678 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Petr Bob Denisa Jasova Gustav Bizik Jiri Raboch Epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.
description	<h4>Background</h4>Alcohol dependence during withdrawal and also in abstinent period in many cases is related to reduced inhibitory functions and kindling that may appear in the form of psychosensory symptoms similar to temporal lobe epilepsy frequently in conditions of normal EEG and without seizures. Because temporal lobe epileptic activity tend to spread between hemispheres, it is possible to suppose that measures reflecting interhemispheric information transfer such as electrodermal activity (EDA) might be related to the psychosensory symptoms.<h4>Methods and findings</h4>We have performed measurement of bilateral EDA, psychosensory symptoms (LSCL-33) and alcohol craving (ACQ) in 34 alcohol dependent patients and 32 healthy controls. The results in alcohol dependent patients show that during rest conditions the psychosensory symptoms (LSCL-33) are related to EDA transinformation (PTI) between left and right EDA records (Spearman r = 0.44, p<0.01).<h4>Conclusions</h4>The result may present potentially useful clinical finding suggesting a possibility to indirectly assess epileptiform changes in alcohol dependent patients.
format	article
author	Petr Bob Denisa Jasova Gustav Bizik Jiri Raboch
author_facet	Petr Bob Denisa Jasova Gustav Bizik Jiri Raboch
author_sort	Petr Bob
title	Epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.
title_short	Epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.
title_full	Epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.
title_fullStr	Epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.
title_full_unstemmed	Epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.
title_sort	epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/d69916ae618c4872836cd66510b4ca8b
work_keys_str_mv	AT petrbob epileptiformactivityinalcoholdependentpatientsandpossibilitiesofitsindirectmeasurement AT denisajasova epileptiformactivityinalcoholdependentpatientsandpossibilitiesofitsindirectmeasurement AT gustavbizik epileptiformactivityinalcoholdependentpatientsandpossibilitiesofitsindirectmeasurement AT jiriraboch epileptiformactivityinalcoholdependentpatientsandpossibilitiesofitsindirectmeasurement
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Epileptiform activity in alcohol dependent patients and possibilities of its indirect measurement.

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