Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness

Abstract Self-reported skin discomfort is a common problem during pregnancy, but it is not clear whether skin barrier function is altered in the process. Few studies have described the skin barrier function during pregnancy. In this work, we used highly sensitive and high-resolution ultra performanc...

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Autores principales:	Manli Yang, Mingyue Zhou, Yuan Li, Hong Huang, Yan Jia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d69927f6f1b04cbca7b7c1649973f730
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spelling	oai:doaj.org-article:d69927f6f1b04cbca7b7c1649973f7302021-12-02T10:44:21ZLipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness10.1038/s41598-021-82624-32045-2322https://doaj.org/article/d69927f6f1b04cbca7b7c1649973f7302021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82624-3https://doaj.org/toc/2045-2322Abstract Self-reported skin discomfort is a common problem during pregnancy, but it is not clear whether skin barrier function is altered in the process. Few studies have described the skin barrier function during pregnancy. In this work, we used highly sensitive and high-resolution ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to distinguish skin surface lipid (SSL) combined with multivariate analysis of lipids and metabolic changes to determine the relationship between SSL changes and skin physiology during pregnancy in order to better understand the skin condition of pregnant women. The results showed a significant reduction in the total lipid content in pregnant women. A total of 2270 lipids were detected, and the relative abundances of fatty acyls and glycerolipids were significantly reduced, while glycerophospholipids (GPs), sphingolipids, and saccharolipids was significantly increased in the pregnancy group. Multivariate data analysis indicated that 23 entities constituted the most important individual species responsible for the discrimination and phosphatidylcholine was the most abundant lipid in pregnancy group. In addition, compared to SSL profile of control group, it was observed that the average chain length of ceramides and fatty acids both decreased in SSL profile of pregnancy group. The main and most commonly affected pathway was that of GP pathways. These findings indicate that skin lipids are significantly altered in mid-pregnancy compared to the control group. Changes in ostrogen during pregnancy also make the skin more susceptible to inflammatory factors and lead to more fragile and susceptible skin, weakening the skin barrier along with the lipid alterations.Manli YangMingyue ZhouYuan LiHong HuangYan JiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manli Yang Mingyue Zhou Yuan Li Hong Huang Yan Jia Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness
description	Abstract Self-reported skin discomfort is a common problem during pregnancy, but it is not clear whether skin barrier function is altered in the process. Few studies have described the skin barrier function during pregnancy. In this work, we used highly sensitive and high-resolution ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to distinguish skin surface lipid (SSL) combined with multivariate analysis of lipids and metabolic changes to determine the relationship between SSL changes and skin physiology during pregnancy in order to better understand the skin condition of pregnant women. The results showed a significant reduction in the total lipid content in pregnant women. A total of 2270 lipids were detected, and the relative abundances of fatty acyls and glycerolipids were significantly reduced, while glycerophospholipids (GPs), sphingolipids, and saccharolipids was significantly increased in the pregnancy group. Multivariate data analysis indicated that 23 entities constituted the most important individual species responsible for the discrimination and phosphatidylcholine was the most abundant lipid in pregnancy group. In addition, compared to SSL profile of control group, it was observed that the average chain length of ceramides and fatty acids both decreased in SSL profile of pregnancy group. The main and most commonly affected pathway was that of GP pathways. These findings indicate that skin lipids are significantly altered in mid-pregnancy compared to the control group. Changes in ostrogen during pregnancy also make the skin more susceptible to inflammatory factors and lead to more fragile and susceptible skin, weakening the skin barrier along with the lipid alterations.
format	article
author	Manli Yang Mingyue Zhou Yuan Li Hong Huang Yan Jia
author_facet	Manli Yang Mingyue Zhou Yuan Li Hong Huang Yan Jia
author_sort	Manli Yang
title	Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness
title_short	Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness
title_full	Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness
title_fullStr	Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness
title_full_unstemmed	Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness
title_sort	lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d69927f6f1b04cbca7b7c1649973f730
work_keys_str_mv	AT manliyang lipidomicanalysisoffacialskinsurfacelipidrevealsthecausesofpregnancyrelatedskinbarrierweakness AT mingyuezhou lipidomicanalysisoffacialskinsurfacelipidrevealsthecausesofpregnancyrelatedskinbarrierweakness AT yuanli lipidomicanalysisoffacialskinsurfacelipidrevealsthecausesofpregnancyrelatedskinbarrierweakness AT honghuang lipidomicanalysisoffacialskinsurfacelipidrevealsthecausesofpregnancyrelatedskinbarrierweakness AT yanjia lipidomicanalysisoffacialskinsurfacelipidrevealsthecausesofpregnancyrelatedskinbarrierweakness
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Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness

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