Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas
The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves.
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Nature Portfolio
2019
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oai:doaj.org-article:d6a0a59accc9488fa4d118ffc7d1f1f92021-12-02T16:58:19ZCell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas10.1038/s41467-019-11745-12041-1723https://doaj.org/article/d6a0a59accc9488fa4d118ffc7d1f1f92019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11745-1https://doaj.org/toc/2041-1723The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves.Shingo KomuraKenji ItoSho OhtaTomoyo UkaiMio KabataFumiaki ItakuraKatsunori SemiYutaka MatsudaKyoichi HashimotoHirofumi ShibataMasamitsu SoneNorihide JoKazuya SekiguchiTakatoshi OhnoHaruhiko AkiyamaKatsuji ShimizuKnut WoltjenManabu OzawaJunya ToguchidaTakuya YamamotoYasuhiro YamadaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
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| spellingShingle |
Science Q Shingo Komura Kenji Ito Sho Ohta Tomoyo Ukai Mio Kabata Fumiaki Itakura Katsunori Semi Yutaka Matsuda Kyoichi Hashimoto Hirofumi Shibata Masamitsu Sone Norihide Jo Kazuya Sekiguchi Takatoshi Ohno Haruhiko Akiyama Katsuji Shimizu Knut Woltjen Manabu Ozawa Junya Toguchida Takuya Yamamoto Yasuhiro Yamada Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas |
| description |
The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves. |
| format |
article |
| author |
Shingo Komura Kenji Ito Sho Ohta Tomoyo Ukai Mio Kabata Fumiaki Itakura Katsunori Semi Yutaka Matsuda Kyoichi Hashimoto Hirofumi Shibata Masamitsu Sone Norihide Jo Kazuya Sekiguchi Takatoshi Ohno Haruhiko Akiyama Katsuji Shimizu Knut Woltjen Manabu Ozawa Junya Toguchida Takuya Yamamoto Yasuhiro Yamada |
| author_facet |
Shingo Komura Kenji Ito Sho Ohta Tomoyo Ukai Mio Kabata Fumiaki Itakura Katsunori Semi Yutaka Matsuda Kyoichi Hashimoto Hirofumi Shibata Masamitsu Sone Norihide Jo Kazuya Sekiguchi Takatoshi Ohno Haruhiko Akiyama Katsuji Shimizu Knut Woltjen Manabu Ozawa Junya Toguchida Takuya Yamamoto Yasuhiro Yamada |
| author_sort |
Shingo Komura |
| title |
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas |
| title_short |
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas |
| title_full |
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas |
| title_fullStr |
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas |
| title_full_unstemmed |
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas |
| title_sort |
cell-type dependent enhancer binding of the ews/atf1 fusion gene in clear cell sarcomas |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/d6a0a59accc9488fa4d118ffc7d1f1f9 |
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