First theoretical determination of relative biological effectiveness of very high energy electrons

Abstract Very high energy electrons (VHEEs, E > 70 MeV) present promising clinical advantages over conventional beams due to their increased range, improved penumbra and relative insensitivity to tissue heterogeneities. They have recently garnered additional interest in their application to spati...

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Autores principales:	Rachel Delorme, Thongchai A. M. Masilela, Camille Etoh, François Smekens, Yolanda Prezado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6a24da328784cd1ac91194e074ff2d2
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spelling	oai:doaj.org-article:d6a24da328784cd1ac91194e074ff2d22021-12-02T15:00:55ZFirst theoretical determination of relative biological effectiveness of very high energy electrons10.1038/s41598-021-90805-32045-2322https://doaj.org/article/d6a24da328784cd1ac91194e074ff2d22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90805-3https://doaj.org/toc/2045-2322Abstract Very high energy electrons (VHEEs, E > 70 MeV) present promising clinical advantages over conventional beams due to their increased range, improved penumbra and relative insensitivity to tissue heterogeneities. They have recently garnered additional interest in their application to spatially fractionated radiotherapy or ultra-high dose rate (FLASH) therapy. However, the lack of radiobiological data limits their rapid development. This study aims to provide numerical biologically-relevant information by characterizing VHEE beams (100 and 300 MeV) against better-known beams (clinical energy electrons, photons, protons, carbon and neon ions). Their macro- and microdosimetric properties were compared, using the dose-averaged linear energy transfer ( $$\overline{{L_{d} }}$$ L d ¯ ) as the macroscopic metric, and the dose-mean lineal energy $$\overline{{y_{d} }}$$ y d ¯ and the dose-weighted lineal energy distribution, yd(y), as microscopic metrics. Finally, the modified microdosimetric kinetic model was used to calculate the respective cell survival curves and the theoretical RBE. From the macrodosimetric point of view, VHEEs presented a potential improved biological efficacy over clinical photon/electron beams due to their increased $$\overline{{L_{d} }}$$ L d ¯ . The microdosimetric data, however, suggests no increased biological efficacy of VHEEs over clinical electron beams, resulting in RBE values of approximately 1, giving confidence to their clinical implementation. This study represents a first step to complement further radiobiological experiments.Rachel DelormeThongchai A. M. MasilelaCamille EtohFrançois SmekensYolanda PrezadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rachel Delorme Thongchai A. M. Masilela Camille Etoh François Smekens Yolanda Prezado First theoretical determination of relative biological effectiveness of very high energy electrons
description	Abstract Very high energy electrons (VHEEs, E > 70 MeV) present promising clinical advantages over conventional beams due to their increased range, improved penumbra and relative insensitivity to tissue heterogeneities. They have recently garnered additional interest in their application to spatially fractionated radiotherapy or ultra-high dose rate (FLASH) therapy. However, the lack of radiobiological data limits their rapid development. This study aims to provide numerical biologically-relevant information by characterizing VHEE beams (100 and 300 MeV) against better-known beams (clinical energy electrons, photons, protons, carbon and neon ions). Their macro- and microdosimetric properties were compared, using the dose-averaged linear energy transfer ( $$\overline{{L_{d} }}$$ L d ¯ ) as the macroscopic metric, and the dose-mean lineal energy $$\overline{{y_{d} }}$$ y d ¯ and the dose-weighted lineal energy distribution, yd(y), as microscopic metrics. Finally, the modified microdosimetric kinetic model was used to calculate the respective cell survival curves and the theoretical RBE. From the macrodosimetric point of view, VHEEs presented a potential improved biological efficacy over clinical photon/electron beams due to their increased $$\overline{{L_{d} }}$$ L d ¯ . The microdosimetric data, however, suggests no increased biological efficacy of VHEEs over clinical electron beams, resulting in RBE values of approximately 1, giving confidence to their clinical implementation. This study represents a first step to complement further radiobiological experiments.
format	article
author	Rachel Delorme Thongchai A. M. Masilela Camille Etoh François Smekens Yolanda Prezado
author_facet	Rachel Delorme Thongchai A. M. Masilela Camille Etoh François Smekens Yolanda Prezado
author_sort	Rachel Delorme
title	First theoretical determination of relative biological effectiveness of very high energy electrons
title_short	First theoretical determination of relative biological effectiveness of very high energy electrons
title_full	First theoretical determination of relative biological effectiveness of very high energy electrons
title_fullStr	First theoretical determination of relative biological effectiveness of very high energy electrons
title_full_unstemmed	First theoretical determination of relative biological effectiveness of very high energy electrons
title_sort	first theoretical determination of relative biological effectiveness of very high energy electrons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6a24da328784cd1ac91194e074ff2d2
work_keys_str_mv	AT racheldelorme firsttheoreticaldeterminationofrelativebiologicaleffectivenessofveryhighenergyelectrons AT thongchaiammasilela firsttheoreticaldeterminationofrelativebiologicaleffectivenessofveryhighenergyelectrons AT camilleetoh firsttheoreticaldeterminationofrelativebiologicaleffectivenessofveryhighenergyelectrons AT francoissmekens firsttheoreticaldeterminationofrelativebiologicaleffectivenessofveryhighenergyelectrons AT yolandaprezado firsttheoreticaldeterminationofrelativebiologicaleffectivenessofveryhighenergyelectrons
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First theoretical determination of relative biological effectiveness of very high energy electrons

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