Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

Trapped ion mobility (TIMS)-mass spectrometry with parallel accumulation-serial fragmentation (PASEF) facilitates high-sensitivity proteomics experiments. Here, the authors expand TIMS and PASEF to small molecules and demonstrate fast and comprehensive lipidomics of low biological sample amounts.

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Autores principales: Catherine G. Vasilopoulou, Karolina Sulek, Andreas-David Brunner, Ningombam Sanjib Meitei, Ulrike Schweiger-Hufnagel, Sven W. Meyer, Aiko Barsch, Matthias Mann, Florian Meier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d6a409c3b2024cd59469965a92c59566
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spelling oai:doaj.org-article:d6a409c3b2024cd59469965a92c595662021-12-02T17:31:41ZTrapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts10.1038/s41467-019-14044-x2041-1723https://doaj.org/article/d6a409c3b2024cd59469965a92c595662020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14044-xhttps://doaj.org/toc/2041-1723Trapped ion mobility (TIMS)-mass spectrometry with parallel accumulation-serial fragmentation (PASEF) facilitates high-sensitivity proteomics experiments. Here, the authors expand TIMS and PASEF to small molecules and demonstrate fast and comprehensive lipidomics of low biological sample amounts.Catherine G. VasilopoulouKarolina SulekAndreas-David BrunnerNingombam Sanjib MeiteiUlrike Schweiger-HufnagelSven W. MeyerAiko BarschMatthias MannFlorian MeierNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Catherine G. Vasilopoulou
Karolina Sulek
Andreas-David Brunner
Ningombam Sanjib Meitei
Ulrike Schweiger-Hufnagel
Sven W. Meyer
Aiko Barsch
Matthias Mann
Florian Meier
Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
description Trapped ion mobility (TIMS)-mass spectrometry with parallel accumulation-serial fragmentation (PASEF) facilitates high-sensitivity proteomics experiments. Here, the authors expand TIMS and PASEF to small molecules and demonstrate fast and comprehensive lipidomics of low biological sample amounts.
format article
author Catherine G. Vasilopoulou
Karolina Sulek
Andreas-David Brunner
Ningombam Sanjib Meitei
Ulrike Schweiger-Hufnagel
Sven W. Meyer
Aiko Barsch
Matthias Mann
Florian Meier
author_facet Catherine G. Vasilopoulou
Karolina Sulek
Andreas-David Brunner
Ningombam Sanjib Meitei
Ulrike Schweiger-Hufnagel
Sven W. Meyer
Aiko Barsch
Matthias Mann
Florian Meier
author_sort Catherine G. Vasilopoulou
title Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_short Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_full Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_fullStr Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_full_unstemmed Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
title_sort trapped ion mobility spectrometry and pasef enable in-depth lipidomics from minimal sample amounts
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d6a409c3b2024cd59469965a92c59566
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AT karolinasulek trappedionmobilityspectrometryandpasefenableindepthlipidomicsfromminimalsampleamounts
AT andreasdavidbrunner trappedionmobilityspectrometryandpasefenableindepthlipidomicsfromminimalsampleamounts
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